The Crystal Structure of Pyrazinic Acid

スポンサーリンク

概要

• 論文の詳細を見る

• The crystal structure of pyrazinic acid has been determined by X-ray diffraction method. The crystal is orthorhombic, space group Pna2<SUB>1</SUB>, <I>a</I>=11.352, <I>b</I>=7.363, <I>c</I>=6.454Å, and <I>Z</I>=4. The structure was solved by inspecting the sharpened Patterson map. The final <I>R</I> value is 6.4% for all observed reflections. The molecule does not take a zwitter ion, but a neutral form. The dimensions of the pyrazine ring are close to those of pyrazine. Each molecule is joined, through the O–H···N hydrogen bond with distance of 2.669 Å, to two neighboring molecules forming the chain. These chains are linked by the weak C–H···O hydrogen bond to form the sheet parallel to the (0 0 1) plane. This hydrogen bonding scheme is quite similar to that of nicotinic acid. The hydrogen bonding type found in nicotinic acid is considered energetically favored more than that found in picolinic acid.

• 公益社団法人 日本化学会の論文

著者

• Higuchi Taiichi

  Department Of Chemistry Faculty Of Science Osaka City University

• Shimada Akira

  Department of Chemistry Faculty of Science Osaka City University

• Takusagawa Fusao

  Department of Chemistry, Faculty of Science, Osaka City University

• Sasada Yoshio

  Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology

• Tamura Chihiro

  Central Research Laboratories, Sankyo Co., Ltd.

• Tamura Chihiro

  Central Research Laboratories Sankyo Co., Ltd.

関連論文

• Omenn Syndrome-Review of Several Phenotypes of Omenn Syndrome and RAG1/RAG2 Mutations in Japan
• Malignant Insulinoma with Extensive Liver Metastases Presenting as Disturbance of Consciousness
• IMMUNOPATHOLOGICAL FEATURES OF LADA VS. SPIDDM : CURRENT STRATEGY FOR PREVENTION
• IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese
• Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer
• Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype : a study by the Japanese Childhood AML Cooperative Study Group
• Low Frequency of KIT Gene Mutation in Pediatric Acute Myeloid Leukemia with inv(16)(p13q22) : A Study of the Japanese Childhood AML Cooperative Study Group
• ANTIOXIDANT ACCELERATES TRANSFER OF DIABETES INTO AUTOIMMUNE DIABETES OF MICE
• The Feasibility of Altering the Hair Cycle via the Induction of Apoptosis by Cyclosporin A
• Effect of Combination Therapy of a Rapid-Acting Insulin Secretagogue (Glinide) with Premixed Insulin in Type 2 Diabetes Mellitus
• INFLUENCE OF TOLERANCE TO AND PHYSICAL DEPENDENCE ON OPIOID ANALGESICS ON CORTICAL EVOKED POTENTIAL IN RATS
• Binuclear Silver (I) Complex with Double Armed Diaza-Crown Ether Containing Short Metal-Metal Separation
• Beta cell dysfunction and its clinical significance in gestational diabetes
• Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
• Normal glucose tolerance with high HbA1c levels observed in two cases of Hb variants
• Higher level of serum vascular endothelial growth factor in type 2 diabetic patients with diabetic retinopathy hospitalized for hyperglycemic state
• CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
• Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
• Effects of Pretreatment with Low-dose Metformin on Metabolic Parameters and Weight Gain by Pioglitazone in Japanese Patients with Type 2 Diabetes
• Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)
• RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse : a study of the Japanese Childhood AML Cooperative Study Group
• Prevention of disaster
• Glycated albumin to glycated hemoglobin ratio reflects postprandial glucose excursion and relates to beta cell function in both type 1 and type 2 diabetes
• Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes : a possible link suggested by cross-sectional analysis
• Studies on 1,2,4-thiadiazolidine derivatives. I. The synthesis and structural determination of 2,4-disubstituted 3,5-disubstituted imino-1,2,4-thiadiazolidines.
• Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen
• Associations of Insulin Resistance and Glycemic Control with the Risk of Kidney Stones
• Risk for Future Diabetes among Individuals with High-normal Glycemia at 40 Years of Age
• Mode of potentiating action of cocaine in morphine analgesia.
• The Crystal Structure of m-Aminobenzenearsonic Acid
• Studies on 1,2,4-thiadiazolidine derivatives. IV. The isomers of 2,4-disubstituted 3,5-(disubstituted imino)-1,2,4-thiadiazolidines.
• The Crystal and Molecular Structure of Pyromellitic Acid Dihydrate (Benzene-1,2,4,5-tetracarboxylic Acid Dihydrate)
• The Crystal Structure of Quinolinic Acid
• Crystal and molecular structure of (ethyl methacrylate)-bis(triphenylphosphine)nickel(0).
• Complexes between nucleotide base and amino acid. II. Crystal structure of 5-bromocytosine: N-tosyl-L-glutamic acid.
• Crystal and molecular structures of octaethylporphinium(monocation) triiodide and its benzene hemisolvate.
• The crystal and molecular structure of N-carboxy-.GAMMA.-benzyl-L-glutamate anhydride.
• Crystal and molecular structure of methyl D-tetronitroside.
• Structural studies of fortimicins. IV. The crystal structure of fortamine sulfate trihydrate and the anion effect on fortamine conformation.
• Conformation of condensed polycyclic aromatic hydrocarbons. II. The molecular and crystal structure of violanthrene B (dibenzo(a, rst)naphtho(8,1,2-cde)pentaphene).
• Crystal Structure of p-Bromobenzylideneacetone
• Crystal structure of adenine-1-(2-carboxyethyl)uracil (1:1) complex. A model for interactions of amino acid side chains with nucleic acid base pair.
• Crystal structures of mixed ligand copper(II) complexes containing L-amino acids. I. L-asparaginato-L-histidinatocopper(II) and its hydrate.
• Structural studies of asymmetric hydrogenation. IV. The crystal structures of [(R)-1-cyanoethyl][(S)(-)-.ALPHA.-methylbenzylamine]bis(dimethylglyoximato)cobalt(III) at 293 K and 173 K.
• Crystal and molecular structure of antibiotic gilvocarcin M.
• High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia : a study of the Japanese Childhood AML Cooperative Study Group
• A model for interactions of amino acid side chains with Watson-Crick base pair of guanine and cytosine. Crystal structures of 9-(2-carboxyethyl)guanine and its crystalline complex with 1-methylcytosine.
• The Molecular and Crystal Structure of 3,4-Furandicarboxylic Acid Dimethylester
• Crystal Structures of 1-(2-Thiazolylazo)-6-bromo-2-naphthol and Bis(1-(2-thiazolylazo)-2-naphthol)iron(II)
• The Crystal Structure of Dipicolinic Acid Monohydrate
• The Crystal Structure of Cinchomeronic Acid
• The Crystal and Molecular Structure of Nagilactone A Diacetate
• Slowly Progressive Type 1 Diabetes Treated with Metformin for Five Years after Onset
• Preparations and properties of optically active (alkyl)bis(dimethylglyoximato)cobalt(III) complexes.
• The crystal structure of 13H-dibenz(a,de)anthracen-13-one.
• The Crystal Structure of Pyrazinic Acid
• Conformation of condensed polycyclic aromatic hydrocarbons. I. The molecular and crystal structure of anthra(2,1,9,8-hijkl)-benzo(de)naphtho(2,1,8,7-stuv)pentacene.
• Reactions of .ALPHA.-aminoacetonitriles with isothiocyanates. Synthesis of 1,3-disubstituted 5-imino-2-thiohydantoins.
• Studies on 1-(thiosulfinylaminothio)piperidines.
• The crystal and molecular structure of echinosporin.
• Structure of Fusariocin C, A Cytotoxic Metabolite from Fusarium Moniliforme
• The Crystal and Molecular Structure of 2,5-Distyrylpyrazine
• The Crystal and Molecular Structure of Butein Monohydrate, Isolated from Dahlia variabilis
• The Crystal and Molecular Structure of Miyaconitine Hydrobromide Dihydrate
• The crystal structure of a stable benzocyclobutene. II. 2,7-Di-t-butyl-10,10,11,11-tetracyano-4,5,9,12-tetraphenyltetracyclo[6.4.0.03,6.09,12]dodeca-1(8),2,4,6-tetraene.
• The Crystal and Molecular Structure of 4,10b-Methano-8H-benzo[ab]cyclodecen-8-one
• Structural studies of cyclo(L-histidyl-L-histidyl) and its metal complexes.
• Structural studies of asymmetric hydrogenation. II. The crystal structure of methyl(R(+)-.ALPHA.-methylbenzylamine)bis(dimethylglyoximato)cobalt(III) benzene solvate.
• Structural studies on fortimicins. III. The crystal and molecular structure of fortamine dihydrochloride.
• Overproduction and preliminary X-ray characterization of aspartate aminotransferase from Escherichia coli.

もっと見る 閉じる

スポンサーリンク