C-24 Stereochemistry of Marine Sterols : (22E)-24-(Isopropenyl)-22-dehydrocholesterol and 24-Isopropenylcholesterol
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概要
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The C-24 configuration of (22E,24ξ)-24-isopropenyl-22-dehydrocholesterol (1), which was recently isolated from the Colombian Caribbean sponge, Topsentia ophiraphidites, was investigated. Synthesis of the stereodefined (24R)- and (24S)-(22E)-24-isopropenyl-22-dehydrocholesterols (1a, 1b) followed by ^1H- and ^<13>C-NMR data comparison of these sterols established the (24R)-configuration of 1. In addition, (24R)- and (24S)-24-isopropenylcholesterols (2a and 2b) were also synthesized and their NMR data are provided. The C-24 configurations of the samples of 24-isopropenyleholesterol reported previously are discussed.
- 社団法人日本薬学会の論文
- 2006-10-01
著者
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HARA Noriyuki
Department of Chemistry and Materials Science, Tokyo Institute of Technology
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FUJIMOTO Yoshinori
Department of Chemistry and Materials Science, Tokyo Institute of Technology
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DUQUE Carmenza
Departamento de Quimica, Universidad Nacional de Colombia
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Carderon Gladys
Departamento De Quimica Universidad National De Colombia
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Hara Noriyuki
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Duque Carmenza
Departamento De Quimica Universidad National De Colombia
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Duque Carmenza
Departamento De Quimica Universidad Nacional De Colombia
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ECHIGO Shizue
Department of Chemistry and Materials Science, Tokyo Institute of Technology
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Echigo Shizue
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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FUJIMOTO Yasuo
College of Pharmacy, Nihon University
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Yoshinori Fujimoto
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Fujimoto Yoshinori
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Fujimoto Yoshinori
Department Of Chemistry And Material Science Tokyo Institute Of Technology
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Fujimoto Yasuo
Department Of General Studies College Of Humanities And Sciences Nihon University
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