Optical Resolution and Absolute Configuration of Branched 4-Nonylphenol Isomers and Their Estrogenic Activities
スポンサーリンク
概要
- 論文の詳細を見る
To determine the effects of optical isomerism on the estrogenic activity of 4-nonylphenol (NP) isomers, four optically active NP isomers, (3R)-4-(3-ethyl-2-methylhexan-2-yl)phenol, (3S)-4-(3-ethyl-2-methylhexan-2-yl)phenol, (4R)-4-(2,4-dimethylheptan-4-yl)phenol and (4S)-4-(2,4-dimethylheptan-4-yl)phenol, were prepared and separated using chiral HPLC. Their absolute configurations were elucidated by X-ray crystallographic analysis of their bromobenzoylated derivatives. The estrogenic activities (recombinant yeast screen assay) of the optically active NPs were similar to those of the corresponding racemates.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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UCHIYAMA Taketo
College of Pharmacy, Nihon University
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FUJIMOTO Yasuo
College of Pharmacy, Nihon University
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KATASE Takao
College of Bioresource Sciences, Nihon University
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HASHIZUME Daisuke
RIKEN
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Hashizume Daisuke
Riken (the Institute Of Physical And Chemical Research)
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Saito Hiroaki
College of Pharmacy, Nihon University
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Makino Mitsuko
College of Humanities and Sciences, Nihon University
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Katase Takao
College Of Bioresource Sciences Nihon University
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Makino Mitsuko
College Of Humanities And Sciences Nihon University
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Fujimoto Yasuo
Coll. Of Humanities And Sciences Nihon Univ.
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Fujimoto Yasuo
College Of Humanities And Sciences Nihon University
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Uchiyama Taketo
College Of Pharmacy Nihon University
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Saito Hiroaki
College Of Pharmacy Nihon University
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