Optical Resolution and Absolute Configuration of Branched 4-Nonylphenol Isomers and Their Estrogenic Activities

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概要

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• To determine the effects of optical isomerism on the estrogenic activity of 4-nonylphenol (NP) isomers, four optically active NP isomers, (3R)-4-(3-ethyl-2-methylhexan-2-yl)phenol, (3S)-4-(3-ethyl-2-methylhexan-2-yl)phenol, (4R)-4-(2,4-dimethylheptan-4-yl)phenol and (4S)-4-(2,4-dimethylheptan-4-yl)phenol, were prepared and separated using chiral HPLC. Their absolute configurations were elucidated by X-ray crystallographic analysis of their bromobenzoylated derivatives. The estrogenic activities (recombinant yeast screen assay) of the optically active NPs were similar to those of the corresponding racemates.

• 公益社団法人日本薬学会の論文
• 2007-04-01

著者

• UCHIYAMA Taketo

  College of Pharmacy, Nihon University

• FUJIMOTO Yasuo

  College of Pharmacy, Nihon University

• KATASE Takao

  College of Bioresource Sciences, Nihon University

• HASHIZUME Daisuke

  RIKEN

• Hashizume Daisuke

  Riken (the Institute Of Physical And Chemical Research)

• Saito Hiroaki

  College of Pharmacy, Nihon University

• Makino Mitsuko

  College of Humanities and Sciences, Nihon University

• Katase Takao

  College Of Bioresource Sciences Nihon University

• Makino Mitsuko

  College Of Humanities And Sciences Nihon University

• Fujimoto Yasuo

  Coll. Of Humanities And Sciences Nihon Univ.

• Fujimoto Yasuo

  College Of Humanities And Sciences Nihon University

• Uchiyama Taketo

  College Of Pharmacy Nihon University

• Saito Hiroaki

  College Of Pharmacy Nihon University

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