Simultaneous Analysis of Residual 4-Alkylphenols in Synthetic Resin Products for Drug and Food Use Using Head-Space Gas Chromatography-Mass Spectrometry (HS-GC/MS)
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概要
- 論文の詳細を見る
Investigation of the amounts of chemical substances excreted into environments is important in the consideration of their influence on humans and other biologics. We performed this study to investigate the excretion levels of 4-alkylphenols, represented by the endocrine disrupters 4-octylphenol and 4-nonylphenol, from chemical products and established a simultaneous analytical method in which 4-alkylphenols were trimethylsilylated and analyzed using head-space gas chromatography-mass Spectrometry (HS-GC/MS). This is a simple and innovative method that proceeds to derivatization with a one-step procedure and dissolves the whole sample as well as eliminates impurities interfering with analysis. When this method was applied to synthetic resin products, 4-nonylphenol (detection limit 0.5μg/ml) was rapidly and simply analyzed with high sensitivity.
- 公益社団法人日本薬学会の論文
- 2007-06-01
著者
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UCHIYAMA Taketo
College of Pharmacy, Nihon University
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FUJIMOTO Yasuo
College of Pharmacy, Nihon University
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Nakagawa Tomoo
Yokohama City Institute Of Health
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Saito Hiroaki
College of Pharmacy, Nihon University
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Sakurai K
Department Of Basic Sciences The University Of Tokyo
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Katase Takao
Coll. Of Bioresource Sciences Nihon Univ.
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Fujimoto Yasuo
Coll. Of Humanities And Sciences Nihon Univ.
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Fujimoto Yasuo
College Of Humanities And Sciences Nihon University
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Sakurai Katsumi
Yokohama City Institute Of Health
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Sugaya Naeko
Yokohama City Institute of Health
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Takahashi Kunio
Meiji Pharmaceutical University
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Uchiyama Taketo
College Of Pharmacy Nihon University
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Sakurai K
Yokohama City Institute Of Health
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Saito Hiroaki
College Of Pharmacy Nihon University
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