Mechanism of C-2 Hydroxylation during the Biosynthesis of 20-Hydroxyecdysone in Ajuga Hairy Roots

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概要

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• Feeding synthetic [2β-^2H]- and [2α-^2H]-cholesterols to the hairy roots of Ajuga reptans var. atropurpurea and ^2H-NMR analysis of the biosynthesized 20-hydroxyecdysone revealed that hydroxylation at C-2 proceeds with retantion of configuration. Feeding [2α, 3α-^2H_2]cholesterol followed by ^2H-NMR analysis of the 2,3,22-triacetate of the resulting 20-hydroxyecdysone ruled out a mechanism which involves a partial loss of the 2α-hydrogen. The steric course of C-2 hydroxylation in Ajuga hairy roots is identical with that reported in the insect, Schistocerca gregaria.

• 公益社団法人日本薬学会の論文
• 2000-03-01

著者

• Nomura Keiko

  Department of Pediatrics, Toyama University School of Medicine

• FUJIMOTO Yoshinori

  Department of Chemistry and Materials Science, Tokyo Institute of Technology

• Nomura Keiko

  Department Of Chemistry And Materials Science Tokyo Institute Of Technology

• Fujimoto Yoshinori

  Department Of Chemistry And Materials Science Tokyo Institute Of Technology

• Fujimoto Yoshinori

  Department Of Chemistry And Material Science Tokyo Institute Of Technology

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