ANTIHYPERTENSIVE ACTIVITY OF ORALLY ADMINISTERED METHYL O-(4-HYDROXY-3-METHOXYCINNAMOYL) RESERPATE (CD-3400) IN CONSCIOUS HYPERTENSIVE RATS
スポンサーリンク
概要
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Antihypertensive activity of orally administered methyl O-(4-hydroxy-3-methoxycinnamoyl)reserpate (CD-3400) was examined and compared with such activity of reserpine and its related agents in conscious hypertensive rats. CD-3400, 4-16 mg/kg p.o., produced a marked antihypertensive effect lasting 6 hr and a slight decrease in heart rate in spontaneously hypertensive rats (SHR). Reserpine, 1-4 mg/kg, rescinnamine, 4-16 mg/kg, and syrosingopine, 8-32 mg kg p.o., produced effects similar to those of CD-3400. The order of antihypertensive activities of the agents was as follows: reserpine>CD-3400=rescinnamine>syrosingopine. In renal hypertensive rats and deoxycorticosterone hypertensive rats, CD-3400 and rescinnamine, 4-16 mg/kg, and reserpine, 1-4 mg/kg p.o., also produced an antihypertensive effect and the order of potency was as follows: reserpine>rescinnamine≥CD-3400. Repeated administrations of CD-3400, 2-12 mg/kg/day p.o., for 14 days, to SHR produced the marked constant antihypertensive effects during the administration period. The order of the potency was as follows: reserpine> rescinnamine>CD-3400. CD-3400 possessing a sustained antihypertensive activity may be prescribed in cases when long-term therapy is required for hypertensive patients.
- 社団法人 日本薬理学会の論文
著者
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Fujimoto Yasuo
Department Of General Studies College Of Humanities And Sciences Nihon University
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kato Hitoshi
Department Of Pediatrics Kurume University School Of Medicine
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NAKAO Kenichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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TAMADA Terumi
Department of Research Institute, Nippon Chemiphar Co., Ltd.
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KAMISHIRO Toshio
Department of Research Institute, Nippon Chemiphar Co., Ltd.
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Kato Hitoshi
Department Of Pediatrics Graduate School Of Medicine University Of Tokyo
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FUJIMOTO Yasuo
Department of Research Institute, Nippon Chemiphar Co., Ltd.
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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