SMOOTH MUSCLE RELAXING DRUGS AND GUINEA PIG ILEUM
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概要
- 論文の詳細を見る
The effects of various smooth muscle relaxing drugs on contractile responses to acetylcholine (ACh), Ba<SUP>2+</SUP> and Ca<SUP>2+</SUP>, and on the tissue cyclic AMP levels were examined in the guinea pig ileum. Papaverine and theophylline caused a decrease both in the maximum height and the slope of dose-response curves induced by the three stimulants, and an increase in the cyclic AMP levels. Diltiazem and D-600 produced a decrease in the maximum and the slope of ACh and Ba<SUP>2+</SUP> dose-response curves, shifted the Ca<SUP>2+</SUP> dose-response curves to higher concentrations, in a parallel manner, but failed to change the cyclic AMP levels. Etomidoline and benactyzine shifted the curves for the three stimulants in parallel to the right, but at higher concentrations depressed the maximum of ACh and Ba<SUP>2+</SUP> responses with a further parallel shift. These drugs exerted little influence on the basal level of tissue cyclic AMP, but etomidoline significantly depressed the Ba<SUP>2+</SUP>-induced increase in cyclic AMP level. The smooth muscle relaxing drugs used could be classified in three types, thereby suggesting that there are at least three different mechanisms involved in smooth muscle relaxing action.
- 社団法人 日本薬理学会の論文
著者
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Mukai Teiichi
Department Of Pharmaceutical Facutly Of Pharmaceutical Sciences Science University Of Tokyo
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Mukai Teiichi
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Yamaguchi Eiichi
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Goto Jun
Department Of Anatomy Showa University School Of Medicine
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YAMAGUCHI Eiichi
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Science, Science University of Tokyo
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MUKAI Teiichi
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Science, Science University of Tokyo
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TAKAGI Keijiro
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Science, Science University of Tokyo
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