EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID OR TAUROCHOLIC ACID-INDUCED GASTRIC LESIONS AND SECRETORY CHANGES IN PYLORUS-LIGATED RATS UNDER NORMAL OR STRESS CONDITIONS
スポンサーリンク
概要
- 論文の詳細を見る
An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric mucosa in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dosedependent. Stress itself (23°C, 7 hr) did not induce any appreciable changes in gastric mucosa of rats. L-glutamine, given together with ASA or TCA, significantly prevented the potentiated development of ASA- or TCA-induced gastric lesions in stressed rats. L-glutamine also prevented in varying degrees the reduction of acid and increment of Na<SUP>+</SUP> ion in gastric juice accumulated in stressed rats in response to ASA or TCA.
- 社団法人 日本薬理学会の論文
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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OKABE Susumu
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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HUNG Chen-Road
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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