Enhancement of Peptone-Induced Gastric Acid Secretion in Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
We compared the acid secretory response to peptone in normal and streptozotocin-induced diabetic rats. Animals were injected with streptozotocin and used after 5 weeks of diabetes with blood glucose levels of >350mg/dl. Under urethane anesthesia, 2ml peptone solution (2-8%) was instilled in the stomach through an acute fistula every 30min. Peptone increased acid secretion in a concentration-dependent manner in normal rats, the maximal response being obtained at 8%. Likewise, the increased acid response was observed in diabetic rats, yet the maximal response observed at 4% was significantly greater than that in normal rats. In both cases, this response was inhibited potently by famotidine as well as YM-022 (a CCKB antagonist) and partially inhibited by atropine. Peptone increased luminal histamine and plasma gastrin levels in both normal and diabetic rats, and the former response was significantly greater in diabetic animals. The altered acid secretion and histamine output in diabetic rats were reverted by insulin treatment. Pentagastrin- but not histamine-induced acid secretion was also increased in diabetic rats. We conclude that peptone-induced acid secretion is increased in diabetic conditions. This phenomenon is insulin-dependent and associated with an enhanced release of histamine but not with an increased sensitivity of the parietal cells.
- 社団法人 日本薬理学会の論文
- 2000-12-01
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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Tashima Kimihito
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Takeuchi K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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FUJITA Akinobu
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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NISHIJIMA Masato
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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Fujita Akinobu
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Nishijima Masato
Department Of Biomaterials Osaka Dental University
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Nishijima Masato
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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