Protective Effect of Thiaton an Antispasmodic Drug, Against Indomethacin-Induced Intestinal Damage in Rats
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概要
- 論文の詳細を見る
The effect of thiaton [3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide], an antispasmodic drug, on indomethacin-induced intestinal damage was examined in rats. The animals were given indomethacin, s.c., and the intestinal mucosa was examined 24 h later. Thiaton or atropine was given s.c. twice, 30 min before and 8 h following indomethacin. Indomethacin caused intestinal damage, accompanied with increase in enterobacterial translocation as well as inducible nitric oxide synthase (iNOS) and myeloperoxidase (MPO) activities, and these changes were significantly prevented by supplementation with 16,16-dimethyl prostaglandin E2 (dmPGE2). Treatment of the animals with thiaton dose-dependently prevented the intestinal damage, together with the suppression of MPO and iNOS activities, and these effects were similarly observed by atropine. The increase of bacterial translocation was also significantly prevented by both thiaton and atropine, similar to dmPGE2. Indomethacin enhanced intestinal motility, and this effect was inhibited by either thiaton, atropine or dmPGE2. The intestinal mucus and fluid secretions were decreased by indomethacin but enhanced by dmPGE2. Both thiaton and atropine slightly decreased these secretions under basal conditions but significantly reversed the decrease in the secretions caused by indomethacin. These results suggest that thiaton protects the small intestine against indomethacin-induced damage and inflammatory changes, and this effect is related with prevention of enterobacterial translocation, the process being associated with inhibition of intestinal hypermotility caused by indomethacin, probably due to anti-muscarinic action.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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Takeuchi Koji
Div. Of Pathological Sciences Dep. Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutica
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Kato Shinichi
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Takeuchi K
Global Warming Control Department National Institute For Resources And Environment
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MIYAZAWA Tohru
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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KUNIKATA Tomonori
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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KANATSU Kenji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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Kunikata Tomonori
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Kanatsu Kenji
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Kato Shinichi
Div. Of Pathological Sciences Dep. Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutica
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Miyazawa Tohru
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Takeuchi Koji
Division Of Pathological Sciences Department Of Pharmacology And Experimental Therapeutics Kyoto Pha
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Kato Shinichi
Department Of Materials Science And Engineering Graduate School Of Engineering Nagoya University
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Takeuchi Koji
Department Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutical University.
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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Kato Shinichi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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