Effects of Helicobacter pylori Infection on Gastric Parietal Cells and E-cadherin in Mongolian Gerbils
スポンサーリンク
概要
- 論文の詳細を見る
Atrophic gastritis caused by infection with Helicobacter pylori is characterized by parietal cell loss, which is a main risk factor for gastric cancer. Parietal cells play a crucial role in the regulation of cell lineage maturation and proliferation in the gastric units. Among the classical cadherins, E-cadherin plays an important role not only in epithelial cell–cell connections, but also in the maintenance of epithelial polarity and gastric glandular architecture and regulation of cell proliferation. The aim of this study is to elucidate how parietal cells and E-cadherin are altered in gastritis with Helicobacter pylori infection. We studied the effects of Helicobacter pylori on gastric mucosal E-cadherin 2 weeks after inoculation and investigated the relationship between parietal cell loss and the amount of E-cadherin on parietal cells in Mongolian gerbils. The number of parietal cells and amount of staining of E-cadherin below the isthmus were investigated by immunohistochemistry. It was shown that a reduction in intercellular E-cadherin preceded the disappearance of parietal cells. The gastric glands where parietal cells were lost were replaced by mucus secreting cells without E-cadherin. These results suggest that Helicobacter pylori damaged E-cadherin on parietal cells and caused massive parietal cell loss, leading to the deregulation of gastric morphology.
- 公益社団法人 日本薬理学会の論文
著者
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Takahashi Rei
Department Of Pathology And Tumor Biology Graduate School Of Medicine Kyoto University
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Sugiyama Akiko
Department Of Nutrition And Food Science Ochanomizu University
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Yamamoto Mika
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Amagase Kikuko
Department Of Applied Pharmacology Kyoto Pharmaceutical University
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Murakami Motonobu
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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Sugiyama Akiko
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Yamamoto Mika
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Fukuzawa Mayu
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Hamaya Kanako
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Tamura Yuumi
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Murakami Toshiko
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Japan
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Fukuzawa Mayu
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Tamura Yuumi
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Hamaya Kanako
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Takeuchi Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Japan
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Takahashi Rei
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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Takahashi Rei
Department of Health and Sports Sciences, Faculty of Education, Chiba University
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Murakami Motonobu
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan
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