Significance of the Level of Monocyte Chemoattractant Protein-1 in Human Atherosclerosis : Assessment in Chronic Hemodialysis Patients
スポンサーリンク
概要
- 論文の詳細を見る
Background Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP- 1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions An increase in MCP-1 may be an important factor in the progression of atherosclerosis in nondiabetic HD patients.
- 社団法人日本循環器学会の論文
- 2004-06-20
著者
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Ohe Tohru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medical and Dentistry
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Morita Hiroshi
Department of Cardiology, Shingu Munichipal Hospital
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Kimura Hideo
国立病院機構岡山医療センター 循環器科
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Nishii Nobuhiro
Department of Cardiovascular Medicine Okayama University
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Nakamura Kazufumi
Department of Cardiovascular Medicine Okayama University
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Ikeda Tetsuya
Department of Cardiovascular Medicine, Okayama University
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Miura Aya
Department of Cardiovascular Medicine, Okayama University
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Banba Kimikazu
Department of Cardiovascular Medicine, Okayama University
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Hata Katsuya
Department Of Physiology Kawasaki Medical School
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Nishii Nobuhiro
Department Of Cardiology Okayama University Graduate School Of Medicine
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Emori Tetsuro
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Hisamatsu Kenichi
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Hisamatsu Kenichi
国立病院機構岡山医療センター 循環器科
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Hata Katsuya
Department Of Physiology Kawasaki Medical University
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OHTA Keiko
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Fujio Hideki
Division Of Cardiology Himeji Red Cross Hospital
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Fujio Hideki
Department Of Cardiovascular Medicine Japanese Red Cross Society Himeji Hospital
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Nakamura Yoichi
Department of Cardiology, Ehime Prefectural Central Hospital
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Ohe Tohru
Department Of Cardiovascular Medicine Okayama University
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Kimura Hideo
Department Of Cardiology National Hospital Organization Okayama Medical Center
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Saito Hironori
Departments Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Saito Hironori
Department Of Cardiology Okayama Red Cross General Hospital
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Matsumori Akira
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Nakamura Yoichi
Department Of Cardiovascular Medicine Matsuyama Shimin Hospital
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Kusano Hitoshi
Fukushima-Naika Clinic
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Hashimoto Katsushi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
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Yamamoto Mika
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
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Kusano Isao
Fukushima-Naika Clinic
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Nakamura Kazufumi
Department Of Cardiology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Ohta Keiko
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Ohta Keiko
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
-
Yamamoto Mika
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Ikeda Tetsuya
Department Of Cardiovascular Medicine Okayama University
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Ikeda Tetsuya
Department Of Cardiology Okayama Red Cross General Hospital
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Nakamura Yoichi
Department Of Cardiology Ehime Prefectural Central Hospital
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Hisamatsu Kenichi
Department Of Cardiology National Hospital Organization Okayama Medical Center
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Matsumori A
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Ohta Keiko
Department Of Pathology National Cardiovascular Center
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Banba Kimikazu
Department Of Cardiovascular Medicine Okayama University
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Banba Kimikazu
Department Of Cardiology Kochi Health Sciences Center
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Nakamura Yoichi
Department Of Cardiovascular Medicine
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Hashimoto Katsushi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Miura Aya
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Hisamatsu Kenichi
Division Of Cardiology National Hospital Organization Okayama Medical Center
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Koyama Keiko
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Fujio Hideki
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Hashimoto Ken
Department Of Physiology Kawasaki Medical University
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Nakamura Kazufumi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Ikeda Tetsuya
Department Of Applied Physics Faculty Of Engineering Hokkaido University
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Hashimoto Katsushi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Saitoh Hironori
Departments Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Nakanishi Norifumi
Departments Of Internal Medicine National Cardiovascular Center
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Morita Hiroshi
Department Of Applied Chemistry School Of Engineering Kanagawa University
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Ohe Tohru
Department Of Cardiology Okayama University
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Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University
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Hashimoto Katsushi
Department of Applied Chemistry, School of Engineering, The University of Tokyo
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NAKAMURA Kazufumi
Department of Applied Chemistry, Tokai University
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Fujio Hideki
Department of Cardiology, Japanese Red Cross Society Himeji Hospital, Japan
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Nakamura Kazufumi
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
-
NAKAMURA Yoichi
Department of Aerospace Engineering, Nagoya University
-
FUJIO Hideki
Department of Cardiology, Japanese Red Cross Society Himeji Hospital
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