Cytoprotective Effect of Plasmin Inhibitor on Necrotizing Agent-Induced Gastric Lesions in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential difference induced by 50% ethanol and 1 % ammonia. The protection of gastric mucosa afforded by tranexamic acid and aminocaproic acid was not affected by pretreatment with indomethacin (5 mg/kg). These results suggest that plasmin inhibitor plays an important role in the prevention of gastric deep necrosis following exposure of the stomach to a damaging agent.
著者
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Saita Hiroshi
Department Of Gastroenterology Hyogo Prefectural Amagasaki Hospital
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Murakami Motonobu
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Matsuo Keiji
Department of Electrical Engineering, Faculty of Engineering, Fukuoka Institute of Technology, Wajirohigashi 3-30-1 Higashi-ku, Fukuoka 811-0295, Japan
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YOO Jung
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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TERAMURA Sanae
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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INADA Masami
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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MIYAKE Takeo
Kyoto National Hospital
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KUSAKA Sigeru
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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MATSUO Keiji
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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