Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of adrenalectomy (AD) on ethanol-induced gastric injury and prostaglandin (PG) protection on the damage were investigated in rats and compared with those of N-ethylmaleimide (NEM), a sulfhydryl (SH) blocker, and diethyl maleate (DEM), a SH depletor. Oral administration of 100% ethanol (1 ml) induced elongated bands of hemorrhagic lesions in the corpus mucosa of sham operated rats, and these lesions were significantly prevented by 16, 16-dimethyl PGE<SUB>2</SUB> (dmPGE<SUB>2</SUB>, 10 μg/kg, s.c.). AD markedly enhanced the mucosal ulcerogenic responses caused by ethanol and abolished the protective effect of dmPGE<SUB>2</SUB>; this agent rather worsened the lesions, which appeared throughout the corpus mucosa. AD by itself enhanced the microvascular permeability in the gastric mucosa without any effect on SH contents. These alterations caused by AD were significantly reverted by hydrocortisone treatment (10 mg/kg/day for 2 weeks, s.c.). On the other hand, a single injection of NEM (10 mg/kg, s.c.) similarly enhanced the vascular permeability, worsened the ethanol-induced lesion, and mitigated the protective effect of dmPGE<SUB>2</SUB> without altering mucosal SH contents, while DEM (1 ml/kg, s.c.) significantly reduced the mucosal SH levels and the lesions. These results suggest that AD worsened the mucosal lesions induced by ethanol, probably by enhancing the ricrovascular permeability, and this action may be due to a lack of steroid secretion but is not directly related to a mucosal SH deficiency.
- 公益社団法人 日本薬理学会の論文
著者
-
Hara Nobuyuki
Department Of Chemistry Tokyo Institute Of Technology:department Of Biochemistry University Of Wisco
-
Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
-
Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
-
OKADA Megumu
Department of Applied Pharmacology, Kyoto Pharmaceutical University
-
NISHIWAKI Hideyuki
Department of Applied Pharmacology, Kyoto College of Pharmacy
-
HARA Nobuyuki
Department of Applied Pharmacology, Kyoto Pharmaceutical University
関連論文
- Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice
- A NEW METABOLITE OF VITAMIN D_2 AND BIOLOGICAL ACTIVITIES OF ITS ANALOGS
- Utilization of Knockout Mice to Examine the Potential Role of Gastric Histamine H_2-Receptors in Menetrier's Disease
- Desensitization of Capsaicin-Sensitive Sensory Neurons in Rat Stomachs on Chronic Treatment with Sodium Taurocholate
- Enhanced Gastric Mucosal Damage in Rats after Chronic Treatment with Sodium Taurocholate
- EFFECT OF GLUCOCORTICOID DEFICIENCY ON INDOMETHACIN-INDUCED GASTRIC MICROVASCULAR PERMEABILITY, HYPERMOTILITY AND GASTRIC MUCOSAL INJURY IN RATS
- Alteration of Gastric Ulcerogenic and Healing Responses in Rats With Adjuvant-Induced Arthritis
- Protective Effect of Thiaton an Antispasmodic Drug, Against Indomethacin-Induced Intestinal Damage in Rats
- Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandins, nitric oxide and desensitization of capsaicin-sensitive neurons
- An Overview of Acetic Acid Ulcer Models : The History and State of the Art of Peptic Ulcer Research
- THE MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC ULCERS BY ADRENALECTOMY IN THE RAT
- On theMechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion
- EFFECTS OF METIAMIDE AND PROPRANOLOL ON GASTRIC SECRETION IN ANESTHETIZED DOGS
- INFLUENCE OF AMYLOPECTINE SULFATE ON GASTRIC MUCOSA IN NORMAL OR WATER-IMMERSION STRESSED RATS
- EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID OR TAUROCHOLIC ACID-INDUCED GASTRIC LESIONS AND SECRETORY CHANGES IN PYLORUS-LIGATED RATS UNDER NORMAL OR STRESS CONDITIONS
- EFFECT OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN PREGNANT AND NON-PREGNANT RATS
- EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS
- STIMULATORY EFFECT OF THE WATER EXTRACT OF BAMBOO GRASS (FOLIN SOLUTION) ON GASTRIC ACID SECRETION IN PYLORUS-LIGATED RATS
- EFFECTS OF PHENTOLAMINE MESYLATE AND PROPRANOLOL HYDROCHLORIDE ON ASPIRIN-INDUCED GASTRIC LESIONS AND GASTRIC SECRETION IN THE RAT
- PATHOGENESIS OF GASTRIC LESIONS INDUCED BY ASPIRIN IN THE PYLORUS-LIGATED RAT
- Changes in Gastric Function and Healing of Chronic Gastric Ulcers in Aged Rats
- CHARACTERISTICS OF MILD IRRITANTS AND ADAPTIVE CYTOPROTECTION ; ROLE OF ENDOGENOUS PROSTAGLANDINS IN SELF-DEFENSIVE MECHANISMS
- CHANGES IN TRANSMUCOSAL POTENTIAL DIFFERENCE AND LUMINAL PH IN ANESTHETIZED RAT STOMACH AFTER EXPOSURE TO ETHANOL
- EFFECTS OF VARIOUS DRUGS AND VAGOTOMY ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN THE RAT
- Exogenous Histamine Stimulates Colorectal Cancer Implant Growth via Immunosuppression in Mice
- Roxatidine-and Cimetidine-Induced Angiogenesis Inhibition Suppresses Growth of Colon Cancer Implants in Syngeneic Mice
- Gastroprotective Role of Glucocorticoid Hormones
- EFFECTS OF AN ANTIULCER AGENT, N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX (KW-110) ON THE DUODENAL AND GASTRIC ULCER MODELS IN THE RAT
- Effects of Transforming Growth Factor Alpha and Hepatocyte Growth Factor on Acid-Induced Damage in Rat Gastric Epithelial Cells
- EFFECT OF OMEPRAZOLE ON MORPHOLOGICAL AND FUNCTIONAL CHANGES OF THE GASTRIC MUCOSA IN H. PYLORI-INFECTED MONGOLIAN GERBILS
- Roles of Gastric Motility Changes in Cytoprotection Induced by Acetazolamide and Cysteamine in Rats
- EFFECTS OF N-ACETYL-L-CARNOSINE ALUMINUM (CL-1700) ON VARIOUS ACUTE GASTRIC LESIONS AND GASTRIC SECRETION IN RATS
- STRAIN DIFFERENCES IN ASPIRIN-INDUCED GASTRIC ULCERATION IN RATS
- EFFECTS OF VARIOUS AMINO ACIDS ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS
- EFFECTS OF THE ANTIULCER DRUG GERANYLGERANYLACETONE ON ASPIRIN-INDUCED GASTRIC ULCERS IN RATS
- Tacrolimus (FK506), an Immunosuppressive Agent, Prevents Indomethacin-Induced Small Intestinal Ulceration in the Rat : Inhibition of Inducible Nitric Oxides Synthase Expression
- THE THERAPEUTIC EFFECT OF FM100, A FRACTION OF LICORICE ROOT, ON ACETIC ACID ULCER IN RATS
- ACID BACK-DIFFUSION AND MUCOSAL H+ HANDLING IN THE RAT STOMACH UNDER NORMAL AND STRESS-INDUCED CONDITIONS
- Enhancement of Peptone-Induced Gastric Acid Secretion in Streptozotocin-Induced Diabetic Rats
- EFFECTS OF ANTI-ULCER AGENTS ON THERMAL-CORTISONE-INDUCED ULCERS IN RATS
- EFFECTS OF 15(S)-15-METHYL-PGE2 METHYL ESTER ON HEALING OF CHRONIC GASTRIC AND DUODENAL ULCERS IN RATS
- EFFECT OF L-GLUTAMINE ON INDOMETHACIN-INDUCED GASTRIC LESIONS IN THE RAT
- INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS
- EFFECTS OF CL-1700 ON DUODENAL ULCER FORMATION IN THE RAT
- Role of Thromboxane A_2 in Healing of Gastric Ulcers in Rats
- Mucosal Protective Effect of Leminoprazole on Reflux Esophagitis Induced in Rats
- Recent Advances in Gastrointestinal Pathophysiology : Role of Heat Shock Proteins in Mucosal Defense and Ulcer Healing
- Inhibition of Concanavalin A-Induced Mice Hepatitis by Coumarin Derivatives
- GASTRIC ACID SECRETION IN BEAGLE DOGS USING INTRAMUSCULAR INJECTION OF STIMULANTS
- EFFECTS OF CL-1700 AND ITS CONSTITUENTS ON ACUTE OR CHRONIC GASTRIC LESIONS AND GASTRIC SECRETION IN RATS
- Role of the Sympathetic Nervous System in Gastric Functional Changes Induced by Thyrotropin-Releasing Hormone in Rats
- EFFECTS OF L-GLUTAMINE ON ACETYLSALYCYLIC ACID INDUCED GASTRIC LESIONS AND ACID BACK DIFFUSION IN DOGS
- Tacrolimus (FK506), an Immunosuppressive Agent, Prevents Indomethacin-Induced Small Intestinal Ulceration in the Rat: Inhibition of Inducible Nitric Oxide Synthase Expression
- Antisecretory Effect of Leminoprazole on Histamine - Stimulated Gastric Acid Secretion in Dogs: Potent Local Effect
- INFLUENCE OF L-GLUTAMINE ON ASPIRIN-INDUCED GASTRIC LESIONS AND ABSORPTION AS WELL AS ANTIPYRETIC, ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ASPIRIN IN RATS AND MICE
- New Therapeutic Strategy for Amino Acid Medicine : Prophylactic and Healing Promoting Effect of Monosodium Glutamate Against NSAID-Induced Enteropathy
- Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
- A continuous monitoring of mucosal integrity and secretory activity in rat stomach: A preparation using a lucite chamber.
- Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats.
- Pathogenic mechanisms involved in mepirizole-induced duodenal damage in the rat.
- Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock : Comparative study with indomethacin.
- Gastroduodenal HCO3- secretion in anesthetized rats: Effects of 16,16-dimethyl PGE2, topical acid and acetazolamide.
- Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
- Effects of indomethacin on the duodenal mucosa of rats : Comparative study with cysteamine.
- Effects of a New Histamine H2-Receptor Antagonist, Z-300, on Gastric Secretion and Gastro-Duodenal Lesions in Rats: Comparison with Roxatidine.
- Effect of NC-1300-O-3 on Healing of Acetic Acid-Induced Gastric Ulcers in Rats.
- Functional and morphological alterations in the rat stomach following exposure to hypertonic NaCl solution.
- Duodenal Ulcers Induced by Diethyldithiocarbamate, a Superoxide Dismutase Inhibitor, in the Rat: Role of Antioxidative System in the Pathogenesis.
- Cytoprotective action of histamine against 0.6N HCl-induced gastric mucosal injury in rats; Comparative study with adaptive cytoprotection induced by exogenous acid.
- Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats.
- Effects of prostaglandin biosynthesis inhibitors and ouabain on duodenal mucosa and HCO3- secretion in rats.
- Effects of topical application of acidified omeprazole on acid secretion and transmucosal potential difference in anesthetized rat stomachs.
- Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.
- Stimulation by Capsaicin of Gastric Alkaline Secretion in Anesthetized Rats.
- Induction of Gastric Lesions by 2-Deoxy-D-Glucose in Rats Following Chemical Ablation of Capsaicin-Sensitive Sensory Neurons.
- Characterization of Gastric Mucosal Blood Flow Response Induced by Intragastric Capsaicin in Rats.
- Capsaicin-sensitive afferent neurons in adaptive responses of the rat stomach induced by a mild irritant.
- Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach.
- Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
- Effects of Indomethacin and Prednisolone on the Different Stages of Healing of Acetic Acid-Induced Gastric Ulcers in the Rat.
- Effects of a crude extract of a marine dinoflagellate, containing dimethyl-.BETA.-propiothetin, on HClethanol-induced gastric lesions and gastric secretion in rats.
- Mechanism by Which Indomethacin Delays Gastric Ulcer Healing in the Rat: Inhibited Contraction of the Ulcer Base.
- Role of gastric acid and bile acids in the pathogenesis of Compound 48/80-induced gastric lesions in rats.
- Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: Comparative study with hypertonic NaCl.
- Biochemical and pharmacological analysis of 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole (NC-1300), a new proton pump inhibitor.
- Capsaicin-Sensitive Sensory Nerves in Recovery of Gastric Mucosal Integrity after Damage by Sodium Taurocholate in Rats.
- Vinegar is a dietary mild irritant to the rat gastric mucosa.
- Effects of various agents on prednisolone-induced gastric lesions in rats.
- Effect of 16,16-dimethyl prostaglandin E2 on gastric surface epithelial cell damage induced by 20% ethanol in rats.
- Cytoprotective effects of NC-1300 and omeprazole on HClethanol-induced gastric lesions in rats.
- Effects of topical application of KT1-32 on transmucosal potential difference and acid secretion in the rat stomach.
- Effects of 16,16-dimethyl prostaglandin E2 on surface epithelial cell damage in the rat stomach induced by vagal nerve stimulation.
- The relationship of intraduodenal pH and delayed gastric emptying in duodenal ulceration induced by mepirizole or cysteamine in rats.
- Effects of MCI-727, a New Antiulcer Agent, on Various Gastric and Duodenal Lesions in Experimental Animals.
- Cytoprotective Action of L-Arginine against HCl-Induced Gastric Injury in Rats: Involvement of Nitric Oxide?
- Mechanisms Underlying Stimulation of Gastroduodenal HCO3- Secretion by NG-Nitro-L-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Synthase, in Rats.
- Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine monofumarate monohydrate, on gastric lesions and gastric secration in rats.
- Effects of a New Benzimidazole Derivative, NC-1300-O-3, on gastric Secretion and Gastroduodenal Lesions in Rats.
- Pathogenesis of the earliest epithelial cell damage induced by mepirizole and cysteamine in the rat duodenum.
- Histamine-induced villous damage in the rat duodenum.