Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
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概要
- 論文の詳細を見る
We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats. hEGF, given twice daily at 30 and 100 μg/kg for 2 weeks or at 100 μg/kg for 4 weeks to rats with ulcers, had no effect on natural healing or the gastric secretion, delayed one caused by indomethacin. Oral hEGF had no effect on basal histamine-stimulated gastric secretion, and stomach weight. These results indicate that oral hEGF has no biological activity on the pathophysiology of the stomach.
- 公益社団法人 日本薬理学会の論文
著者
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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KUWAHARA Yoshimi
Department of Applied Pharmacology, Kyoto College of Pharmacy
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KUWAHARA Yoshimi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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SUNAGAWA Yoko
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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IMOTO Yoshimi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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