Effects of 16,16-dimethyl prostaglandin E2 on surface epithelial cell damage in the rat stomach induced by vagal nerve stimulation.
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概要
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The effect of 16, 16-dimethyl prostaglandin E<SUB>2</SUB> (dmPGE<SUB>2</SUB>) on gastric surface epithelial cell (SEC) damage induced by vagal nerve stimulation (VS) in urethane-anesthetized rats was studied using scanning electron microscopy. VS (1.25-10 Hz, 0.2 mA, 2 msec, 10 min) resulted in a graded increase in the SEC damage, increased gastric contractions, increased gastric acid secretion, and a decrease in heart rate. Pretreatment with dmPGE2 (0.3-30 μ, g/kg, s.c.) significantly protected the SEC from VS-induced damage, inhibited the increase in gastric contractions and acid secretion, but had no influence on the decrease in heart rate. Atropine (1 mg/kg, s.c.) also protected the SEC from VS-induced damage and inhibited the alterations in response to VS. Timoprazole (30 mg/kg, s.c.) had no protective effects on SEC from VS-induced damage, no effect on increased gastric contractions and heart rate, but did inhibit the increase in gastric acid secretion, in response to VS. These results suggest that: (A) VS-induced SEC damage was caused by increased gastric contractions and not by increased gastric acid secretion, and (B) dmPGE<SUB>2</SUB> protects against SEC damage by inhibiting gastric contractions.
- 公益社団法人 日本薬理学会の論文
著者
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Ohno Tomochika
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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URAMOTO Hiroshi
Laboratory of Experimental Pharmacology, Suntory Institute for Biomedical Research
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Ishihara Takafumi
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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