Difference in Pressor Responses to NG-Monomethyl-L-Arginine between Conscious and Anesthetized Rats.
スポンサーリンク
概要
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N<SUP>G</SUP>-Monomethyl L-arginine (L-NMMA; 0.1-10 mg/kg, i.v.), a selective inhibitor of nitric oxide (NO) synthesis derived from L-arginine, elicited a greater increase in blood pressure in urethane/α-chloralose- and pentobarbital-anesthetized rats than in conscious Wistar rats. The pressor response to phenylephrine was almost equivalent in both conscious and anesthetized rats. These findings suggest that the experimental conditions (anesthetized or conscious) modify the spontaneously released NO's contribution to blood pressure regulation in vivo.
- 公益社団法人 日本薬理学会の論文
著者
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Ishihara Takafumi
Laboratory Of Experimental:molecular Pharmacology Suntory Institute For Biomedical Research
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Aisaka Kazuo
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Mitani Aki
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Kitajima Yasuo
Gene Technology, Suntory Institute for Biomedical Research
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Ohno Tomochika
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Ishihara Takafumi
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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