Effects of Nitric Oxide-Related Compounds and Carperitide on Hemodynamics and hematocrit in Anesthetized Rats.
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概要
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Sodium nitroprusside, nitroglycerin and carperitide (α-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. <I>N<SUP>G</SUP></I>-Monomethyl L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.
- 公益社団法人 日本薬理学会の論文
著者
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Ishihara Takafumi
Laboratory Of Experimental:molecular Pharmacology Suntory Institute For Biomedical Research
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Aisaka Kazuo
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Ohno Tomochika
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Kanai Tadashi
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Hidaka Toshinori
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Miyazaki Tomoko
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Ishihara Takafumi
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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