Pressor effect of NG-monomethyl-L-arginine in SHRSP.
スポンサーリンク
概要
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Pressor effects of N<SUP>G</SUP>-monomethyl-L-arginine (L-NMMA), a selective inhibitor of nitric oxide production from L-arginine, on mean blood pressure (MBP) were investigated in conscious Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). L-NMMA (0.1-10 mg/kg, i.v.) elicited a dose-dependent increase in the MBP of WKY and SHRSP. The pressor response to L-NMMA was more marked in SHRSP than in WKY. These results suggest that nitric oxide may play an important role in the blood pressure regulation in the conscious SHRSP.
- 公益社団法人 日本薬理学会の論文
著者
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Ishihara Takafumi
Laboratory Of Experimental:molecular Pharmacology Suntory Institute For Biomedical Research
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AISAKA Kazuo
Laboratory of Experimental Pharmacolgy, Suntory Institute for Biomedical Research,
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Aisaka Kazuo
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Mitani Aki
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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Kitajima Yasuo
Gene Technology, Suntory Institute for Biomedical Research
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MITANI Aki
Laboratory of Experimental Pharmacolgy, Suntory Institute for Biomedical Research,
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Ishihara Takafumi
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research
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