EFFECTS OF AN ANTIULCER AGENT, N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX (KW-110) ON THE DUODENAL AND GASTRIC ULCER MODELS IN THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
Antiulcer effects of N-acetyl-L-glutamine aluminum complex (KW-110) were studied in experimental gastric and duodenal ulcer models in the rat, comparing its effect to that of atropine sulfate. It was found that KW-110, given orally 3 times daily for 8 days, had an accelerating activity on the healing process of duodenal ulcer whereas atropine sulfate, given s.c. twice daily for 8 days at a glutamine dose to Sufficiently suppress gastric secretion, had a significant effect. In addition, KW-110 showed remarkable effects on prevention of acutely induced experimental gastric ulcers. In regard to the Shay ulcer or aspirin-induced gastric lesions, KW-110 showed enhanced effects which exceeded the apparently maximum effects of atropine sulfate, even though the dosage of the former was much higher than that of the latter. While atropine sulfate completely inhibited the stress-induced gastric lesions, KW-110 also revealed a strong inhibition on the lesions.
- 社団法人 日本薬理学会の論文
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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MORITA Akira
Department of Electronic Engineering,Iwate University
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Nakamura Keita
Department of Cardiology,Fukuoka Wajiro Hospital
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OKABE Susumu
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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Nakamura Keita
Department Of Cardiology Fukuoka Wajiro Hospital
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Morita Akira
Department Of Basic Science Ishinomaki Senshu University
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NAKAMURA Keita
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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TAKEUCHI Koji
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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