Effects of various agents on prednisolone-induced gastric lesions in rats.
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概要
- 論文の詳細を見る
We studied the effects of various agents on prednisolone-induced gastric lesions in rats. Gastric lesions were produced by subcutaneous administration of 50 mg/kg of prednisolone once daily for 4 days to non-fasted rats. Daily oral administration of antipeptic, antisecretory agents and 16-dmPGE<SUB>2</SUB> significantly inhibited the lesions. Antacids and PGI<SUB>2</SUB> had little or no effect. These results suggest that the concomitant use of the above agents with steroid therapy to provide protection of the gastric mucosa warrants further attention.
- 公益社団法人 日本薬理学会の論文
著者
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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NOBUHARA YOUICHI
Department of Applied Pharmacology, Kyoto College of Pharmacy
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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