Protective effect of taurine against ammonia-induced gastric mucosal lesions in rats.
スポンサーリンク
概要
- 論文の詳細を見る
We examined the role of gastric ammonia in the development of gastric lesions in rats. Exposure of the gastric mucosa to ammonia (30 mM) produced microscopic injury, but no macroscopic lesion was observed. However, exposure of the stomach to ammonia in rats subjected to ischemia resulted in macroscopic gastric lesions. The macroscopic lesions were markedly inhibited by pretreatment with taurine, a scavenger of hypochlorous acid (HOCI) and monochloramine (NH<SUB>2</SUB>CI). These results indicate that ammonia is deleterious to gastric mucosa, and monochloramine may be involved in the pathogenesis of ammonia-induced mucosal lesions.
- 公益社団法人 日本薬理学会の論文
著者
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Yamamoto Ko
Department Of Chemical Engineering And Materials Science Doshisha University
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Saita Hiroshi
Department Of Gastroenterology Hyogo Prefectural Amagasaki Hospital
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Murakami Motonobu
Department Of Applied Physics And Chemistry The University Of Electro-communications
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YOO Jung
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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TERAMURA Sanae
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University
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MIYAKE Takeo
National Kyoto Hospital
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