Effects of ammonia on the gastric mucosal barrier in rats and dogs.

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概要

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• We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H<SUP>+</SUP>, Na<SUP>+</SUP> and K<SUP>+</SUP>. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H<SUP>+</SUP> loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na<SUP>+</SUP> and K<SUP>+</SUP> influxes into the lumen. In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H<SUP>+</SUP> loss, and ammonia at concentration of 0.5% increased both Na<SUP>+</SUP> and K<SUP>+</SUP> influxes into the lumen. These results suggest that ammonia breaks the gastric mucosal barrier.

• 公益社団法人 日本薬理学会の論文

著者

• Kita Toru

  Department Of Cardiology Kobe City Medical Center General Hospital

• Saita Hiroshi

  Department Of Gastroenterology Hyogo Prefectural Amagasaki Hospital

• Murakami Motonobu

  Department Of Applied Physics And Chemistry The University Of Electro-communications

• YOO Jung

  Department of Geriatric Medicine, Faculty of Medicine, Kyoto University

• INADA Masami

  Department of Geriatric Medicine, Faculty of Medicine, Kyoto University

• SEIKI Masao

  Department of Geriatric Medicine, Faculty of Medicine, Kyoto University

• TERANUMA Sanae

  Department of Geriatric Medicine, Faculty of Medicine, Kyoto University

• MIYAKE Takeo

  Kyoto National Hospital

• KITA Toru

  Department of Geriatric Medicine, Faculty of Medicine, Kyoto University

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