VASODILATING EFFECT OF CRUDE PLATYCODIN IN ANESTHETIZED DOGS
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概要
- 論文の詳細を見る
The effects of crude platycodin on the coronary and hindquarter vascular beds in anesthetized dogs were studied and compared with those of glyceryl trinitrate, papaverine and Saponin (E. Merck AG.). Crude platycodin in doses of 200 to 800 μg i.a. dose-dependently reduced coronary and hindquarter vascular resistances and the potency was comparable to that of papaverine. Crude platycodin, 4 mg/kg i.v., also caused an increase in coronary and hindquarter blood flows, concomitantly with a transient systemic hypotension. The vasodilating effect of crude platycodin appears to be direct and non-specific on the peripheral blood vessels as in the case of glyceryl trinitrate or papaverine.
- 社団法人 日本薬理学会の論文
著者
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LEE Eun
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kato Hitoshi
Department Of Pediatrics Kurume University School Of Medicine
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NAKAO Kenichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUZUKI Shoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kato Hitoshi
Department Of Pediatrics Graduate School Of Medicine University Of Tokyo
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Lee Eun
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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LEE Eun
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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