STUDIES ON THE HEALING OF EXPERIMENTAL ULCER IN THE RAT II: INFLUENCE OF ANTI-INFLAMMATORY DRUGS ON THE HEALING OF THE ACETIC ACID ULCER AND THE COMPONENTS IN GASTRIC TISSUE

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The relationship between chemical components of the injured portion in acetic acid ulcer and ulcer healing, and the influence of anti-inflammatory drugs on the ulcer were investigated herein. The hexosamine content in the corpus of normal rat stomach was decreased by a 20 day administration of Na salicylate or phenylbutazone. Healing of 10% acetic acid ulcer was delayed remarkably by Na salicylate or phenylbutazone, and hexosamine in the injured portion of the ulcer was decreased simultaneously. Steroidal anti-inflammatory drugs delayed healing of the ulcer, especially in the early stage administration, where hexosamine and hydroxyproline decreased significantly. Sodium salicylate, on the contrary, delayed the ulcer healing in the early and also later stage administration. Lowered hexosamine content in the mucosa and fall of hydroxyproline content in the stroma of the injured portion paralleled the increase of area index and grade index, respectively. In the delayed healing of the ulcer with anti-inflammatory drugs, it was clarified that changes of tissue components of the injured portion immediately after the ulcer formation play an important role in ulcer healing.
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