Effects of panax ginseng root on acquisition of sound discrimination behaviour in rats.
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概要
- 論文の詳細を見る
Pole-climbing and shuttle-avoidance tests were employed to study the acquisition of conditioned avoidance response (CAR) and discrimination behaviour (DB) in male Wistar rats which had been given extracts from Panax Ginseng root intraperitoneally or orally. Neither a lipid soluble fraction (GNo. 5) nor a ginsenoside Rg fraction (GRg) produced significant changes in the acquisition of CAR. GRg given intraperitoneally produced a significant acceleration in the acquisition of DB between a 500 Hz signal sound followed by an electric shock (S<SUP>D</SUP>) and a 1000 Hz signal sound without a shock (S<SUP>J</SUP>) in rats which had learned to avoid the shock following S<SUP>D</SUP> at a rate of over 95 %. Small doses of GNo. 5 produced a significant depression in the acquisition of DB.
- 公益社団法人 日本薬理学会の論文
著者
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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TSUCHIYA Moriyoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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NAKA Shinichi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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