Membrane Effects of Pronethalol on the Mammalian Heart Muscle Fiber
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概要
- 論文の詳細を見る
Actions of pronethalol on the electrophysiological properties of the mammalian heart muscle were investigated. Pronethalol decreased the pacemaker activity of the ventricle (right bundle branch of dog) and of the sinus node (rabbit). Conduction velocity, critical membrane potential and maximum depolarization rate were all reduced by pronethalol. Absolute and relative refractory period were prolonged, and Na-inactivation curve shifted to the right (inhibition of Na-carrier system) by pronethalol, whereas no or little effects, if any, were observed on the resting potential and membrane resistance in resting and acting phases.The mechanism of antiarrhythmic action of pronethalol was discussed, and it was concluded that the mechanism is not the same as that for the wellknown beta-blocking action of pronethalol.
- International Heart Journal刊行会の論文
著者
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kamiyama Akimitsu
Department Of Physiology Teikyo University School Of Medicine
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Shigenobu K.
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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MATSUDA Kojiro
Department of Physiology, Faculty of Medicine, University of Tokyo
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SHIGENOBU Koki
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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