Circus Movement Tachycardia Induced by a Single Premature Stimulus on the Ventricular Sheet : Evaluation of the Leading Circle Hypothesis in the Canine Ventricular Muscle : SYMPOSIUM ON MECHANISM OF PAROXYSMAL TACHYARRHYTHMIAS : 49th Annual Scientific Ses

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概要

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• Mechanisms of ventricular tachycardia induced by local application of a properly timed premature stimulus were studied with routine microelectrode technique and extracellular recordings on a ventricular sheet. Thinly sliced preparations obtained from subepicardial muscle of the canine ventricle were used as an approximation of a two-dimensional model. On these preparations, spontaneously sustained tachycardia easily induced by a single premature stimulus. Since delayed after-depolarizations were never evoked by frequent stimulations even in the K^+-free and high-Ca^<++> media, these tachycardias seemed to be induced by re-entrant and circus movement mechanisms. To analyse the re-entrant mechanisms, action potentials generated by normal driving stimuli were recorded from multiple points (40〜50 points) and the spreads of the depolarization and repolarization phases of the action potentials were mapped. The depolarizing wave front on the map always showed a circular or elliptical pattern. Whenever the pattern of spread of the repolarizing wave was similar to that of the depolarizing wave, sustained tachycardia was never brought about by any premature stimulus. On the other hand, when the map of the spread of the repolarizing wave was very complicated and mixed with that of the depolarizing wave, sustained tachycardia was frequently induced. From the above results, it is suggested that the nonuniform recovery of excitability plays a role in the generation of sustained tachycardia. Moreover, a portion of the unidirectional block of the premature impulse was determined by calculated using the conduction velocity of the premature impulse and the effective refractory period in each cell; then a route of re-entry for the premature impulse was simulated. In additional experiments, tachycardia was always suppressed by lidocaine, but was not suppressed by verapamil. The suppression mechanism of lidocaine appeared to be to bring nonuniform recovery of excitability to uniform recovery. Moreover, the leading circle hypothesis was evaluated on the ventricular muscle in the present experiment and diameters of the leading circle in the ventricular muscle were determined to be 8〜10 mm.

• 社団法人日本循環器学会の論文
• 1986-01-20

著者

• Shibayama Rie

  Department Of Physiology Teikyo University School Of Medicine

• Shibayama Rie

  Department Of Physiology School Of Medicine Teikyo University

• Kamiyama Akimitsu

  Department Of Physiology Teikyo University School Of Medicine

• EGUCHI KENICHI

  Department of Physiology, Teikyo University School of Medicine

• Eguchi Kenichi

  Department Of Physiology Teikyo University School Of Medicine

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• Circus Movement Tachycardia Induced by a Single Premature Stimulus on the Ventricular Sheet : Evaluation of the Leading Circle Hypothesis in the Canine Ventricular Muscle : SYMPOSIUM ON MECHANISM OF PAROXYSMAL TACHYARRHYTHMIAS : 49th Annual Scientific Ses
• A MECHANISM OF ABNORMAL T WAVE ON A NEWLY DESIGNED VENTRICULAR MUSCLE STRIP EXCISED FROM THE CANINE VENTRICLE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
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