Determination of the Antifungal Agent Voriconazole in Human Plasma Using a Simple Column-Switching High-Performance Liquid Chromatography and Its Application to a Pharmacokinetic Study
スポンサーリンク
概要
- 論文の詳細を見る
A simple column-switching high performance liquid chromatographic (HPLC) method that does not require any complicated pretreatment has been developed to determine voriconazole in human plasma samples. An internal standard (IS) and borate buffer (pH 9.0) were added to plasma samples, which were then injected directly into the column-switching HPLC system using MAYI-ODS as a pre-column. The calibration curve for voriconazole showed good linearity in the range of 0.2-10μg/ml in human plasma. The mean RSD (%) value of intra-day (n=6) and inter-day (n=5) precision were less than 5.4% and 8.2%, respectively. This system could make more than three hundred successive, accurate measurements when a washing step with ammonium acetate solution was added. This method was successfully applied to measure the therapeutic voriconazole level in patients' plasma, and was used in a study of voriconazole pharmacokinetics after oral administration.
- 公益社団法人日本薬学会の論文
- 2008-03-01
著者
-
Kobayashi Hikaru
Department Of Surgical Oncology Osaka City University Graduate School Of Medicine
-
OHTA SHIN
Department of Pharmacy, Shinshu University Hospital
-
YAMATO Susumu
Department of Analytical Chemistry, Niigata College of Pharmacy
-
SUZUKI Riho
Department of Chemistry, Graduate School of Science, Osaka University
-
Hirabayashi Kazuko
The Second Department Of Internal Medicine Shinshu University School Of Medicine
-
Ohta Shin
Pharmaceutical Health Care And Sciences Tokyo Univ. Of Pharmacy And Life Sci.
-
Ohta Shin
Department Of Hospital Pharmacy Shinshu University School Of Medicine
-
Suzuki Riho
Department Of Bio-analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Phar
-
大和 進
Pharmaceutical And Analytical Chemistry Niigata Univ. Of Pharmacy And Applied Life Sciences
-
NAKAGAWA Saori
Department of Bio-analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Ph
-
YAMAZAKI Reiko
Department of Bio-analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Ph
-
KUSUHARA Yoko
Department of Bio-analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Ph
-
MITSUMOTO Shoko
Department of Bio-analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Ph
-
SHIMOEDA Sadahiko
Department of Pharmacy, Nagano Red Cross Hospital
-
Hora Kazuhiko
Department Of Hematology Nagano Red Cross Hospital
-
Kobayashi Hikaru
Department Of Hematology Nagano Red Cross Hospital
-
Kusuhara Yoko
Department Of Bio-analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Phar
-
Yamazaki Reiko
Department Of Bio-analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Phar
-
Nakagawa Saori
Department Of Bio-analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Phar
-
Mitsumoto Shoko
Department Of Bio-analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Phar
-
Kodaira H
The Second Department Of Internal Medicine Shinshu University School Of Medicine
-
Kobayashi Hikaru
Department Of Pharmacy Nagano Red Cross Hospital
-
Yamato Susumu
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
Ohta Shin
Department of Functional Molecular Chemistry, Kyoto Pharmaceutical University
関連論文
- Sweet Potato Acid Phosphatase Immobilized on Glutaraldehyde-Activated Aminopropyl Controlled-Pore Glass : Activation, Repeated Use and Enzyme Fatigue
- Sweet Potato Acid Phosphatase Immobilized on Glutaraldehyde-Activated Aminopropyl Controlled-Pore Glass : Activation, Repeated Use and Enzyme Fatigue(Miscellameous)
- DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells
- Primary Leiomyosarcoma of the Breast : Report of a Case
- 14q11 abnormality and trisomy 8q are not common in Japanese T-cell prolymphocytic leukemia
- Clinical Pharmacokinetic Study of Arsenic Trioxide in an Acute Promyelocytic Leukemia (APL) Patient : Speciation of Arsenic Metabolites in Serum and Urine(Pharmacology)
- P6-35 Efficacy and pharmacokinetics of arsenic trioxide for treatment of acute promyelocytic leukemia(APL) : 1. Efficacy for APL of Arsenic trioxide(ATO)(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annu
- Development of Disinfectant Mats and Evaluation of Their Effectiveness
- Preparation and Characteristics of Antibacterial Sepiolite Containing Povidone-Iodine as a Useful Pharmaceutical Product for Patient Care
- Neuroendocrine Carcinoma of the Sigmoid Colon: Report of a Case
- 2, 6-Di-tert-butyl-4-diarylmethylene-2, 5-cyclohexadiene-1-thiones.First Isolable Unannelated Thioquinone Methides
- PJ-525 The Cardiac Function of CAWS-induced Aortitis in DBA/2 Mouse, As a Model of Heart Failure(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Intestinal Diffuse Large B-Cell Lymphoma Associated with Celiac Disease : A Japanese Case
- Liver cirrhosis with marked thrombocytopenia and highly elevated serum thrombopoietin levels
- Low prevalence of a polymorphism of platelet membrane glycoprotein Ibβ associated with noenatal alloimmune thrombocytopenic purpura in Asian populations
- Interface States at Ultrathin Chemical Oxide/Silicon Interfaces Obtained from Measurements of XPS Spectra under Biases
- Interface States for Si-Based MOS Devices with an Ultrathin Oxide Layer : X-Ray Photoelectron Spectroscopic Measurements under Biases
- In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer
- Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass : Report of a Case
- Lymphangioma of the Lesser Omentum Associated with Abdominal Esophageal Carcinoma : Report of a Case
- Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer
- High Performance Liquid Chromatographic Determination of Acetoacetate by Post-Column Derivatization with p-Nitrobenzene Diazonium Fluoroborate
- A Comparative Study of Characteristics of Current-Type and Conventional-Type Cationic Bactericides
- Tacrolimus Related Brady and Tachyarrhythmias in a Familial Amyloid Polyneuropathy Patient who Underwent Partial Liver Transplantation
- Tacrolimus Related Brady and Tachyarrhythmias in a Familial Amyloid Polyneuropathy Patient who Underwent Partial Liver Transplantation
- An Asian Variant of Intravascular Lymphoma Diagnosed Through Splenectomy
- Biochemical Characterization of a Pseudomonas fluorescens Strain Isolated from a Benzalkonium Chloride Solution
- Clinical Significance of Measuring the Blood Concentration of Itraconazole Oral Solution in the Field of Hematology
- Two Different Mechanisms Are Involved in the Extremely High-Level Benzalkonium Chloride Resistance of a Pseudomonas fluorescens Strain
- Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation
- Effect of cyclosporin A on patients with lupus nephritis: a review of the literature
- Determination of the Antifungal Agent Voriconazole in Human Plasma Using a Simple Column-Switching High-Performance Liquid Chromatography and Its Application to a Pharmacokinetic Study
- Effective Blood Concentration of Micafungin for Pulmonary Aspergillosis(Pharmacology)
- Analysis of the Blood Level of Micafungin Involving Patients with Hematological Diseases : New Findings Regarding Combination Therapy with Tacrolimus(Pharmacology)
- Evidence for the Degradation of Maleate Moiety in Chlorpheniramine Maleate Solution Using a Stability-Indicating HPLC Method
- Fungicidal Activity of New Quaternary Ammonium Salts
- Comparative Fungicidal Activity of a New Quaternary Ammonium Salt, N-Alkyl-N-2-hydroxyethyl-N, N-dimethylammonium Butyl Phosphate and Commonly Used Disinfectants
- Initiation of Enzyme Replacement Therapy for an Adult Patient with Asymptomatic Type 1 Gaucher's Disease
- Assessment of Tear Concentrations on Therapeutic Drug Monitoring. III. Determination of Theophylline in Tears by Gas Chromatography/Mass Spectrometry with Electron Ionization Mode
- Determination of Valproic Acid in Serum by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry
- Lymphadenopathy of IgG4-related sclerosing disease : three case reports and review of literature
- Graft failure in cord blood transplantation successfully treated with short-term reduced-intensity conditioning regimen and second allogeneic transplantation
- Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
- Ph^1-Positive Acute Lymphoblastic Leukemia in a Patient with a Germline MEN1 Gene Mutation
- CD56^+ acute myeloid leukemia with monosomy 7
- Three-Dimensional Structure of Natural Convection of Water near the Density Extremum within a Horizontal Annulus
- Simultaneous determination of pregnenolone and 17α-hydroxypregnenolone by semi-micro high-performance liquid chromatography with an immobilized cholesterol oxidase as a pre-column reactor : Application to bovine adrenal fasciculata cells
- Severe Pulmonary Toxoplasmosis Mimicking Viral Pneumonitis after a Third Allogeneic Stem Cell Transplantation in a Man with Acute Lymphoblastic Leukemia
- Phenanthro[4,5-bcd]furan derivatives. VI. Some electrophilic substitution reactions and hydrogenation of 4H-cyclopenta[def]phenanthrene, phenanthro[4,5-bcd]furan, and 4H-benzo[def]carbazole.
- Effect of Polyphenols on Production of Steroid Hormones from Human Adrenocortical NCI-H295R Cells
- Development of Disinfectant Mats and Evaluation of Their Effectiveness.
- Effect of Polyphenols on 3-Hydroxy-3-methylglutaryl-Coenzyme A Lyase Activity in Human Hepatoma HepG2 Cell Extracts
- Asian Variant of Intravascular Lymphoma: Aspects of Diagnosis and the Role of Rituximab