A Comparison of the Effects of Estradiol and 2- and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats.
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概要
- 論文の詳細を見る
Effects of estradiol (E2)and catechol-estrogens (CEs: 2-OHE2 and 4-OHE2)on uterine ornithine decarboxylase (ODC)activity have been compared in immature rats. The intensity of their actions by s.c. (1μg)and intrauterine right-horn (i.u., 25 ng)injection was in the order of: 4-OHE2≥ E2 > 2-OHE2. Although i.u.-injection of E2 caused an increase in ODC activity in the left (intact)-horn, which was about 60% that of the right-horn, the effects by CEs were limited only to the right-horn. The results are consistent with the previous view about the order of the potency of 4-OHE2 and 2-OHE2 and also suggest that locally produced CEs may play a role in the physiological functions of the production site.
- 公益社団法人 日本薬理学会の論文
著者
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DEY Sudhansu
Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Johnson Donald
Department of Obstetrics and Gynecology and Physiology, Ralph L. Smith Research Center, University of Kansas Medical Center
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Dey Sudhansu
Department of Obstetrics and Gynecology and Physiology, Ralph L. Smith Research Center, University of Kansas Medical Center
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