Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6, on Reperfusion-Induced Arrhythmia in Rats
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概要
- 論文の詳細を見る
The present study was designed to determine whether a novel cyclohexane dicarboximide derivative, ST-6, 2-[4-[4-(chlorophenyl)-4-hydroxy-1-piperidinyl]butyl]hexahydro-1H-isoindol-1,3(2H)-dione, prevents reperfusion-induced ventricular arrhythmias. Pentobarbital-anesthetized rats were subjected to left coronary artery occlusion for 4 min followed by 4-min reperfusion, and the incidence of their ventricular arrhythmias was examined. The coronary occlusion of control rats induced ventricular tachycardia and fibrillation, eventually leading to sudden death. The intravenous injection of 0.1 to 2 mg/kg ST-6 prior to the occlusion resulted in a dose-dependent suppression of the ventricular arrhythmias. The suppression of ventricular fibrillation was also observed on the intraperitoneal and intradoudenal administration of 2 to 10 mg/kg ST-6 15 min prior to coronary occlusion. Antiarrhythmic effects of this agent (0.5 mg/kg per min) were compared with those of other antiarrhythmic agents including lidocaine (0.1 mg/kg per min), sematilide (0.3 mg/kg per min), and diltiazem (0.5 mg/kg per min) by administrating the agents from 1 min after the coronary occlusion to the end of 4-min reperfusion. Antiarrhythmic effects of ST-6 were similar in degree to those of lidocaine and diltiazem, whereas no significant prevention by sematilide was seen. The results suggest that ST-6 may be capable of suppressing reperfusion-induced arrhythmias following oral or intravenous administration.
- 社団法人 日本薬理学会の論文
- 2005-05-20
著者
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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TANONAKA Kouichi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Takeo Satoshi
東京薬科大学 第一薬理学
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Takeo Satoshi
Dep. Of Molecular And Cellular Pharmacology Tokyo Univ. Of Pharmacy And Life Sciences Jpn
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Katakami H
Miyazaki Medical School Miyazaki Jpn
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Katakami Hideki
宮崎医科大学 内
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KAJIWARA Hiroshi
Pharmacological Research Laboratories, Drug Safety Testing Center Co., Ltd.
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OHOI Itaru
Pharmacology Section, Laboratory of Biology, Research Laboratories, Pharmacological Group, Nippon Ka
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Takeo S
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Katakami Hideki
3rd Department Of Internal Medicine Medical College
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Takagi Kaori
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Kajiwara Hiroshi
Department Of Pathology Tokai University School Of Medicine
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Tanonaka Kouichi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Kajiwara Hiroshi
Pharmacological Research Laboratories Drug Safety Testing Center Co. Ltd.
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Kajiwara Hiroshi
Department Pathology Of Tokai University School Of Medicine
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Ohoi Itaru
Pharmacology Section Laboratory Of Biology Research Laboratories Pharmacological Group Nippon Kayaku
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Hoya Katsumi
Department Of Neurosurgery Teikyo University Chiba Medical Center
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Tanonaka K
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Katakami Hideki
Departments Of Internal Medicine Miyazaki Medical College
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Kajiwara Hiroshi
Departments Of Pathology School Of Medicine Tokai University
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Katakami H
Department Of Pathology Tokai University School Of Medicine
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