Effects of Nefiracetam on Cerebral Adenylyl Cyclase Activity in Rats with Microsphere Embolism-Induced Memory Dysfunction
スポンサーリンク
概要
- 論文の詳細を見る
The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere emholism-induced memory dysfunction were examined. Sustained cerehral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine learning and memory function, the water maze test was performed from day 7 to day 10 after the operation. The escape latency of the microsphere-embolized (ME) rat in the water maze task was longer than that of the shamoperated (Sham) rat, suggesting that spatial memory dysfunction occurred in the ME rat. Csα and Gi_1/2α protein levels in the cerebral cortex, striatum and hippocampus of the ME rat, when determined on day 11, were similar to those of the Sham rats. The basal AC activity in the striatum, but not in the other two regions, of the ME rat decreased. The AC activity in the presence of 10μM colforsin daropate (Col), a direct stimulator of AC, was increased by approximately 20-fold in sham animals and 7- to 10-fold in the ME rat. Treatment of the ME rat with lOmg/kg/d nefiracetam p.o. from day 1 to day 10 after the operation shortened the escape latency, restored the basal AC activity in the striatum, and reversed the Col-induced increases in AC in these three regions without any changes in the cerebral Gsα and Gi_1/2α protein levels. These results suggest that nefiracetam-mediated activation of AC activity may contribute to the improvement of memory and learning function in sustained cerebral ischemia.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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TANONAKA Kouichi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Takeo S
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takeo Satoshi
Dep. Of Molecular And Cellular Pharmacology Tokyo Univ. Of Pharmacy And Life Sciences Jpn
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Takagi Norio
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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KIKUCHI Kanako
Department of Dermatology, Faculty of Medicine, University of Tokyo
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ANDO Tsuyoshi
Department of Agricultural Chemistry, The University of Tokyo
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Takeo S
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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MIYAKE-TAKAGI Keiko
Department of Pharmacology, Tokyo University of Pharmacy Life Science
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ICHIKAWA Tomonaga
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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OMINO Kunio
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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KAJIHARA Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Takagi Kaori
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Tanonaka Kouichi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Kikuchi K
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:presto Jst Corporation
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Omino Kunio
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Miyake-takagi Keiko
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Takagi Noriko
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takagi Norio
Department Of Intermal Medicine Chubu National Hospital
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Ando Tsuyoshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Kikuchi Kanako
Department Of Dermatology Faculty Of Medicine The University Of Tokyo
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Tanonaka K
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Takagi N
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Kajihara Hiroshi
Department Of Natural History Sciences Faculty Of Science Hokkaido University
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Ichikawa Tomonaga
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Kajihara Hiroshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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