Involvement of Adenosine Receptor, Potassium Channel and Protein Kinase C in Hypoxic Preconditioning of Isolated Cardiomyocytes of Adult Rat
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概要
- 論文の詳細を見る
A possible mechanism for hypoxic preconditioning of adult rat cardiomyocytes was pharmacologically investigated. Isolated cardiomyocytes in all experimental groups were incubated for 120 min under hypoxic conditions followed by 15-min reoxygenation (sustained H/R). Sustained H/R decreased rod-shaped cells. Exposure of the cardiomyocytes to 20-min of hypoxia/30-min reoxygenation (hypoxic preconditioning) attenuated the sustained H/R-induced decrease in rod-shaped cells. The effects of hypoxic preconditioning were abolished by treatment with the protein kinase C (PKC) inhibitor polymyxin B, but abolished by neither the adenosine A1/A2-antagonist sulfophenyl theophylline (SPT) nor the ATP-sensitive potassium channel (KATP channel) blocker glibenclamide. In another series of experiments, cardiomyocytes were incubated without hypoxic preconditioning in the presence of either the PKC activator PMA, adenosine or KATP-channel opener nicorandil and then subjected to sustained H/R. Treatment of the cells with PMA, adenosine or nicorandil mimicked the effects of hypoxic preconditioning. The effects of treatment with adenosine and nicorandil were abolished by polymyxin B treatment. Combined treatment with both SPT and glibenclamide abolished the effects of hypoxic preconditioning, whereas it failed to abolish PMA-induced cytoprotection. These results suggest that the activation of PKC in hypoxic preconditioned cardiomyocytes coupled independently with stimulation of adenosine receptor or opening of KATP channel, either of which is fully enough to exert the cytoprotective effects.
- 社団法人 日本薬理学会の論文
- 1999-05-01
著者
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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TANONAKA Kouichi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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YOSHIDA HIROYUKI
Department of Chemical Engineering, Osaka Prefecture University
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Hayashi Jun-Ichi
Department of Medicine, Keio University
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IWAI Takeshi
Department of Materials Chemistry, Faculty of Engineering, Yokohama National University
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Tanonaka Kouichi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Tanonaka Kouichi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Iwai Takeshi
Department Of Applied Physics Faculty Of Engineering Osaka City University
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Iwai Takeshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Yoshida H
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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NOJIRI Michiko
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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YABE Ken-ichi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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KAWANA Ken-ichiro
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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YAMANE Makiko
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Yabe Ken-ichi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Yamane Makiko
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Nojiri Michiko
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Hayashi Jun-ichi
Department Of Medicine Keio University
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Yoshida Hiroyuki
Department Of Chemical Engineering College Of Engineering Osaka Prefecture University
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Hayashi Jun-ichi
Department Of Gerontology Kyorin University School Of Medicine
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HAYASHI JUN-ICHI
Department of Biochemistry, Saitama Cancer Center Research Institute
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Yoshida Hiroyuki
Department of Chemical Engineerig, University of Osaka Prefecture
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