Gingyo Gedokusan vs Oseltamivir for the Treatment of Uncomplicated Influenza and Influenza-like illness : An Open-label Prospective Study

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概要

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• Background: Gingyo-gedoku-san (GGGS) is an herbal medicine approved for upper respiratory infections in Japan. We conducted an open-label, multi-center, prospective trial, comparing GGGS with oseltamivir in patients with influenza and influenza-like illness (ILI) as a pilot study.Methods: Subjects were healthy persons aged between 16 and 40, and were enrolled from January 12, 2010 to March 24, 2011. Fifteen patients were enrolled in this trial (8 and 7 for GGGS and oseltamivir, respectively). RT-PCR was positive for pandemic influenza A (H1N1) in 10 patients. The patients were provided with either GGGS or oseltamivir for 5 days. The primary outcome was mortality and/or hospitalization 7 days after the initial diagnosis. Body temperature and other clinical characteristics were also evaluated.Results: All patients recovered from illness without complication or hospitalization. The mean time to resolve symptoms for the GGGS and oseltamivir groups was 3.9 days and 3.3 days, respectively (p=0.43). The GGGS group appeared to have a smaller symptom score AUC than the oseltamivir group, (p=0.26). Time to recover activity level appeared to be shorter in the GGGS group (p=0.10), with shorter time to recover health status (p=0.02). Sub-group analysis on patients with positive PCR showed similar results between the two groups.Conclusion: GGGS was associated with symptom improvements resembling oseltamivir for both influenza and ILI. Randomized controlled trials involving larger sample sizes are needed to confirm these results.

著者

• Iwata Kentaro

  Division of Health Risk Management, Research Center for Urban Safety and Security, Kobe University

• Ohji Goh

  Division of Health Risk Management, Research Center for Urban Safety and Security, Kobe University

• Igarashi Wataru

  Division of Infectious Diseases, Kobe University Hospital

• Hirai Midori

  Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric

• Kinoshita Shohiro

  Department Of Clinical Laboratory Kobe University Hospital

• Makino Akiko

  Division Of Virology Department Of Microbiology And Immunology Institute Of Medical Science The Univ

• Uchida Daisuke

  Department Of Applied Chemistry Kanagawa University

• Shinya Kyoko

  Division Of Zoonosis Department Of Microbiology And Infectious Diseases Graduate School Of Medicine

• Yoshida Hiroyuki

  Department Of Chemical Engineering College Of Engineering Osaka Prefecture University

• Abe Yasuhisa

  Department Of Physics Hokkaido University

• Oba Yuichiro

  Department Of Infectious Diseases Kobe University Hospital

• OKA Hideaki

  Department of General Medicine, Kanto Rosai Hospital

• Ohji Goh

  Division of Infectious Diseases Therapeutics, Kobe University Graduate School of Medicine

• Kinoshita Shohiro

  Department of Laboratory Medicine, Kobe University Hospital

• Honjo Midori

  Medical Research Division. Accerise Inc.

• Nishimoto Takashi

  Nishimoto Clinic

• Mitani Kazuo

  Mitani Family Clinic

• Tatsumi Yoshiko

  Mitani Family Clinic

• Ninomiya Hiroyuki

  Ninomiya Medical Clinic

• Higasa Kumi

  Kawasaki Clinic

• Usuki Seiichiro

  Usuki Cardiovascular Clinic

• Kagawa Hiroki

  Division of Infectious Diseases

• Takimoto Kohei

  Department of Anesthesiology and Intensive Care, Osaka University School of Medicine

• Suganaga Rei

  Kameda Family Clinic Tateyama

• Matsuo Hiroo

  Division of Infectious Diseases Therapeutics, Kobe University Graduate School of Medicine

• Horigome Mami

  Division of Infectious Diseases Therapeutics, Kobe University Graduate School of Medicine

• Oka Hideaki

  Department of General Internal Medicine, Kanto Rosai Hospital

• Hirai Midori

  Department of Pharmacy, Kobe University Hospital

• Abe Yasuhisa

  Department of Medicine, Yodogawa Christian Hospital

• Oba Yuichiro

  Department of General Medicine, Osaka General Medical Center

• Uchida Daisuke

  Department of Nephrology and Hypertension, St. Marianna University School of Medicine

• Yoshida Hiroyuki

  Department of Chemical Engineerig, University of Osaka Prefecture

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