The Effects of Monobromobimane on Calcium and Phenylarsineoxide-Induced Mitochondrial Swelling and Cytochrome c Release in Isolated Brain Mitochondria (Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
A possible involvement of inhibitory effects of monobromobimane (MBM), a thiol reagent, on the swelling and the release of cytochrome c in the isolated brain mitochondria was examined. MBM dose-dependently inhibited the calcium and phenylarsineoxide-induced mitochondrial swelling and cytochrome c release. Significant relationships between mitochondrial swelling and cytochrome c release were detected. Furthermore, effects of in vivo treatment with MBM on neuronal cell damage after transient (15min) global ischemia in rats were examined. Infusion of MBM (1 or 3μg/animal) to cerebral ventricles attenuated an increased number of TUNEL-positive cells and neuronal cell death in the hippocampal CA1 region at 72 h of reperfusion. These results suggest that MBM may have an ability to inhibit mitochondria-associated apoptotic pathways through attenuation of the mitochondrial swelling and the release of cytochrome c.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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TANONAKA Kouichi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Takeo Satoshi
東京薬科大学 第一薬理学
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Takeo S
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takeo Satoshi
Dep. Of Molecular And Cellular Pharmacology Tokyo Univ. Of Pharmacy And Life Sciences Jpn
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Takagi Norio
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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ABE Tsutomu
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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NAKANO Midori
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Takagi Kaori
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Tanonaka Kouichi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Nakano M
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Abe Tsutomu
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takagi Noriko
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takagi Norio
Department Of Intermal Medicine Chubu National Hospital
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Tanonaka K
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Takagi N
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Ando T
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Abe Tsutomu
Department Of Epidemiology And Health Promotion Tokyo Metropolitan Institute Of Gerontology
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Abe Tsutomu
Department of Chemistry, Faculty of Science and Technology, Sophia University
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