72-kDa Stress Protein (Hsp72) Induced by Administration of Dimethylarsinic Acid to Mice Accumulates in Alveolar Flat Cells of Lung, a Target Organ for Arsenic Carcinogenesis
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概要
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Our previous studies have demonstrated that the oral administration of dimethylarsinic acid (DMA), a main metabolite of inorganics aresemics in mammals, in mice causes DNA damage in the lung as well as the promotion and progression of lung- and skin-tumorigenesis. Moreover, we indicated that 72-kDa stress protein (Hsp72) was induced in cultured human pulmonary (L-132) cells by exposure to DMA and was accumulated specifically in the cell nuclei. The present in vivo study reveals the induction of Hsp72 by intraperitoneal administration of DMA to A/J mice used previously as an animal model of dimethylarsenic-induced lung tumorigenesis. The Hsp72 was observed in the lung, a target organ for arsenic carcinogenesis in human, and in the kidney as well, but not in the liver and spleen. By immunohistochemical analysis, the Hsp72 in lungs was exhibited to exist in the nuclei of alveolar flat cells, including capillary endothelial cells, which were previously found to increase the clumping of heterochromatin, an early morphological change in the developmental process of pulmonary carcinomas, after administration of DMA to mice. These in vivo observations suggest that the increase and accumulation of Hsp72 by administration of DMA to mice may occur specifically in target organs for arsenic carcinogenesis.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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山中 健三
日本大学薬学部環境衛生学ユニット
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Nakano Masayuki
National Mito Hospital
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Okada S
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Okada S
Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Okada S
Tokyo Medical Univ. Tokyo
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Okada S
Kumamoto Univ. Kumamoto Jpn
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Okada S
Univ. Shizuoka Shizuoka Jpn
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Kato K
College Of Pharmacy Nihon University
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Kato Katsuaki
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Yamanaka Kenzo
College Of Pharmacy Nihon University
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Yamanaka Kenzo
Nihon University College Of Pharmacy
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Yamanaka Kenzo
Department Of Pharmacy College Of Science And Technology Nihon University
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HASEGAWA AKIRA
Nihon University, College of Pharmacy
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NAKANO MASAYUKI
Chiba University, Research Center for Pathologenic Fungi and Microbial Toxicoses
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OKADA SHOJI
University of Shizuoka, School of Pharmaceutical Sciences
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KATO Koichi
Nihon University College of Pharmacy
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NARA MASATO
Shizuoka Prefectural Fisheries Experiment Station
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Hasegawa A
College Of Pharmacy Nihon University
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Nakano M
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Nakano Masatake
Thin Film Soi Group.process Engineering Dept.isobe R&d Shin-etsu Handotai Co. Ltd.
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Yamanaka K
Department Of Internal Medicine Nagoya National Hospital:tokai Area Central Hospital For Aids Treatm
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Nakano M
National Mito Hospital
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Hasegawa Akira
Department Of Pharmacy College Of Science And Technology Nihon University
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