Human Neutrophil Elastase Degrades Inter-α-Trypsin Inhibitor to Liberate Urinary Trypsin Inhibitor Related Proteins
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概要
- 論文の詳細を見る
Urinary trypsin inhibitor (UTI) is a physiological protease inhibitor and inter-α-trypsin inhibitor (ITI) is regarded as a precursor of UTI. The purpose of this study is to determine the mechanism of the UTI release from ITI. To examine this, ITI was digested by human neutrophil elastase at various concentrations, and UIT-related proteins which were of the same size as UTI were obtained. The amino acid sequence of the 15 amino acid residues at the N-terminal of UTI-related proteins, corresponded to that of UTI. The amino acid sequences of the small amount of peptides detected corresponded to those of peptides from the heavy chain1 (H1) and the heavy chain2 (H2) of ITI, suggesting that most UTI-related proteins do not combine with peptides from the H1 and H2 of ITI. It was also revealed that UTI-related proteins have several physiological activities similar to those of UTI, i.e., human trypsin inhibitory activity, human neutrophil elastase inhibitory activity, inhibition o tumor necrosis factor-α (TNF-α) production from rat macrophages and of superoxide from rabbit leukocytes.These results demonstrated that ITI is a precursor of UTI which is digested by human neutrophil elastase to release UTI, and that its elastase inhibitory activity is derived from UTI.
- 社団法人日本薬学会の論文
- 1998-07-15
著者
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Yamashiro Kazuya
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Yamashiro Kazuya
Biosciences Research Laboratory Mochiea Pharmaceutical Co. Ltd.
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Kato K
College Of Pharmacy Nihon University
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Kato Katsuaki
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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HIROSE Jiro
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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OZAWA Toshiko
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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MIURA Toshihisa
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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ISAJI Mitsuko
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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NAGAO Yuji
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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NII Atsushi
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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UEMURA Akio
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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Nagao Y
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Hirose J
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Hirose Jiro
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd
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Nii A
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Nii Atsushi
Biosciences Research Laboratory Mochida Pharmaceutical Co. Led.
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Uemura Akio
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Uemura Akio
Institute For Chemical Research Kyoto University
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Isaji Mitsuko
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Isaji Mitsuko
Bioscience Laboratory Mochida Pharmaceuticals
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Ozawa Toshiko
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Miura Toshihisa
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
関連論文
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