Effects of Monochlorobimane on Cerebral Ischemia-Induced Damage to Mitochondria(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
A possible involvement of inhibitory effects of monochlorobimane (MCB) on the opening of mitochondrial permeability transition (MPT) pore in the cerebroprotection against the ischemic brain injury was examined. MCB (1 mM) inhibited the opening of MPT pore in vitro. Sustained cerebral ischemia was induced by injecting 900 microspheres (48μm in diameter) into the right hemisphere of rats. At 12 to 72 h after microsphere embolism (ME), the mitochondrial activity was determined histochemically by staining cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) of the brain sections. The COX and SDH stainings in the hippocampus were observed intensively in the pyramidal neurons in the CA2-3 and dentate gyrus rather than those in the CA-1 region. The staining was decreased with time after the embolism. Pretreatment with 10 μg/animal MCB 30 min prior to the embolism significantly attenuated the ME-induced reduction in the staining of COX and SDH in the hippocampus, but not in the pariatal cortex. The results suggest that prevention of the opening of MPT pore by MCB may play an important role in the cerebroprotection against cerebral ischemic injury.
- 公益社団法人日本薬学会の論文
- 2004-02-01
著者
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Takeo Satoshi
東京薬科大学 第一薬理学
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Takeo S
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takeo Satoshi
Dep. Of Molecular And Cellular Pharmacology Tokyo Univ. Of Pharmacy And Life Sciences Jpn
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Takagi Norio
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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ABE Tsutomu
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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OSHIKAWA Sayuri
Department of Pharmacology, Tokyo University of Pharmacy Life Science
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MIYAKE-TAKAGI Keiko
Department of Pharmacology, Tokyo University of Pharmacy Life Science
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KURUHARA Yoshitada
Division of Pathology, Safety Research Facility of Shin Nippon Biochemical Laboratories
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Abe Tsutomu
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Miyake Keiko
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Miyake-takagi Keiko
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Takagi Noriko
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takagi Norio
Department Of Intermal Medicine Chubu National Hospital
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Takagi N
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Ando T
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Abe Tsutomu
Department Of Epidemiology And Health Promotion Tokyo Metropolitan Institute Of Gerontology
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Oshikawa Sayuri
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Abe Tsutomu
Department of Chemistry, Faculty of Science and Technology, Sophia University
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