Relationship between Changes in Regional Myocardial Contraction and Energy Metabolism Following Coronary Flow Reduction

スポンサーリンク

概要

• 論文の詳細を見る

• To investigate the relationship between mechanical and metabolic deterioration in the ischemic myocardium following a decrease of coronary blood flow, the patterns of regional myocardial contraction and myocardial adenosine triphosphate (ATP) content were analyzed simultaneously in canine left ventricles with constriction of the left anterior descending coronary artery (LAD). The patterns of contraction in the ischemic region were monitored by means of ultrasonic dimension gauges implanted in the endocardial surface and were classified into 5 types; Type 0=normal, Type I=late systolic lengthening, Type II=early and late systolic lengthening with end diastolic length elongation, Type III=systolic bulge with early diastolic shortening, and Type IV=holosystolic bulge. Type I developed in 6/8 dogs with 1-49% LAD flow reduction, Type II in 6/8 dogs with 50-74% reduction, and Types III and IV in all dogs with 75-100% reduction. The myocardial ATP content (μM/Gm tissue) at the sites of the patterns of myocardial contraction measurement was analyzed. No differences in ATP content were noted between Type 0 and Type I (3.70±0.51 vs. 3.60±0.36). In contrast, the ATP content in Type II was significantly reduced (2.94±0.20) compared to Type I (p<0.005). In Types III+IV with systolic bulge, the ATP reductions were severer (2.59±0.36) than in Type II (p<0.05). In conclusion, it can be said that as the LAD flow reduction advanced, the patterns of myocardial contraction were transformed from Type 0 to Type IV with accompanying ATP reductions.

• International Heart Journal刊行会の論文

著者

• Ogawa Satoshi

  Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine

• Takahashi Masando

  Cardiopulmonary Division Departments Of Internal Medicine

• Hayashi Junichi

  Cardiopulmonary Division Department Of Medicine Keio University

• Hattori Shigehiko

  Cardiopulmonary Division, Department of Internal Medicine, Keio University

• Mori Hidezo

  Cardiology Division Department Of Internal Medicine Keio University School Of Medicine

• Nakamura Yoshiro

  Cardiopulmonary Division, Department of Geriatrics, School of Medicine, Keio University

• Nakamura Yoshiro

  Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine

• Ogawa Satoshi

  Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine

• Hattori Shigehiko

  Cardiopulmonary Division Department Of Internal Medicine Keio University

• Hata Junichi

  Department Of Medicine Radiology And Pathology School Of Medicine Tokai University

• OHSUZU Fumitaka

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• HARA Kuniko

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• TANABE Yoshio

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• Hayashi Jun-ichi

  Department Of Medicine Keio University

• Takahashi Masando

  Cardiopulmonary Division Department Of Internal Medicine Keio University

• Nakamura Yoshiro

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• HATTORI Shigehiko

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• HAYASHI Junichi

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• OGAWA Satoshi

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

• TAKAHASHI Masando

  Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University

関連論文

• FRS-035 Pathological Angiogenesis in Human Cardiac Valves is Accompanied by Decreased ChM-I and Augmented VEGF-A and MMP Expression(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Japanese Randomized Trial for Investigation of a Combined Therapy of Amiodarone and Implantable Cardioverter Defibrillator in Patients With Ventricular Tachycardia and Fibrillation : The Nippon ICD Plus Pharmacologic Option Necessity (NIPPON) Study Design
• PJ-140 Efficacy and Feasibility of Pericardial Endoscopy by Percutaneous Subxiphoid Approach(PJ024,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-874 Novel Three-dimensional Image for the Visualization of Coronary Sinus Orifice by unenhanced Computed Tomography(Heart failure, clinical(21)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-107 High velocity peak of ventricular septum during isovolumic contraction period in patients with non-ischemic cardiomyopathy predicts the response to CRT(Echo/Doppler(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanes
• 6 Clinical Backgrounds and Outcomes of Sudden Cardiac Arrest and Syncope Related to Coronary Vasospasm(Symposium 2 (SY-02) (IHD) Coronary Spasm Revisited,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Novel Post-Processing Image for the Visualization of the Coronary Sinus by Multidetector-Row Computed Tomography Before Cardiac Resynchronization Therapy : Edge-Enhanced Image
• OE-249 Quantitative Assessment of Unipolar Electrogram for Optimal Ablation Targets of Right Ventricular Outflow Tract Ventricular Tachycardia(Arrhythmia, therapy-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-086 Innovative Three Dimensional Image Facilitates the Identification of the Ridge Formed by Left Pulmonary Vein Antrum and Left Atrial Appendage(Arrhythmia (clinical) ; Pathophysiology of Atrial Fibrillation, The 71st Annual Scientific Meeting of the
• OE-235 Transplantation of Artificial Epiardiac Accessory Pathway on Rats with Complete Atrio-Ventricular Block, in Vivo(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
• Left Atrial Size and Recent Onset of the Atrial Fibrillation/Flutter Predict the Efficacy of Nifekalant(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Age-Adjusted Heart Rate Variability as an Index of the Severity and Prognosis of Heart Failure
• OE-168 Atf4 Plays a Key Role in Antioxidant Stress Response in the Heart(OE29,Molecular Biology Myocardium (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-905 Remodeling of Cardiac Energy Metabolism under Oxidative Stress to Enhance Regeneration and de novo Synthesis of Glutathione(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
• PE-568 Contribution of Bone Marrow-derived Cells on Pressure Overload-induced Cardiac Hypertrophy and Perivascular Fibrosis in Mice(Regeneration (angiogenesis/myocardial regeneration)-4, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
• OE-255 Bone Marrow-derived Cells are Mobilized and Contribute to Cardiac Hypertrophy via Cell Fusion and Transdifferentiation Mechanism(Regeneration (angionenesis/myocardial regeneration)-1 (M) OE43,Oral Presentation (English),The 70th Anniversary Annual
• Bone Marrow-derived Cells Contribute to Pulmonary Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension (Pulmonary Circulation 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Non-hematopoietic Mesenchymal Stem Cells can be Mobilized and Differentiate into Cardiomyocytes after Myocardial Infarction(Development and Differentiation 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-397 Bone marrow-derived regenerated cardiomyocytes after myocardial infarction were not originated from hematopoietic stem cells(Apoptosis/Necrosis/Regeneration 2 (M) : PE68)(Poster Session (English))
• OE-138 Neural Crest Stem Cells Supply Intrinsic Cardiac Adrenergic Cells and Contribute to Reinnervation after Myocardial Infarction in Mice(OE24,Autonomic Nervous System (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese C
• PJ-905 Remodeling of Cardiac Energy Metabolism under Oxidative Stress to Enhance Regeneration and de novo Synthesis of Glutathione(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
• PE-168 Overexpression of Human C-Reactive Protein Deteriorates Diabetic Cardiomyopathy through the Activation of Renin-Angiotensin System(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• PE-096 Persistent elevation in troponin T during convalescence is associated with anemia and inflammatory response in patients with decompensated heart failure(Heart failure, clinical(07)(M),Poster Session(English),The 72nd Annual Scientific Meeting of th
• 1 Cardiomyocyte Differentiation from Embryonic Stem Cells(Regenerative Medicine of the Cardiovascular Field,Japan-Korea Cardiovascular Conference,Presidential Planning Program (M),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulat
• PE-085 Novel technique for fabricating myocardial cell sheet using polymerized fibrin-coated dishes(Tissue Engineering (H) : PE15)(Poster Session (English))
• OE-132 Demonstration of Electrical Disconnection of the Cell Sheets between Cardiomyocytes and Skeletal Muscle Cells by Optical Mapping(Arrhythmia, Basic 4 (A) : OE16)(Oral Presentation (English))
• Differential Effects of Carvedilol and Metoprolol on Renal Function in Patients With Heart Failure
• PE-168 Overexpression of Human C-Reactive Protein Deteriorates Diabetic Cardiomyopathy through the Activation of Renin-Angiotensin System(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• FRS-035 Short-term Experience of Immunoadsorption Therapy for Refractory Heart Failure due to Dilated Cardiomyopathy(FRS7,Challenging Approaches to Heart Failure Treatment (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The J
• 3 Epoprostenol Therapy for Patients with PAH(The Drug of Choice for Idiopathic Pulmonary Arterial Hypertension,Roundtable Discussion 5 (RT-5) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-746 Effectiveness of Sildenafil Pre-administration before Epoprostenol Therapy in Pulmonary Arterial Hypertension with Right Heart Failure(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulat
• PJ-004 High Mobility Group Box 1 Protein is associated with Post-Infarction Healing Process and Left Ventricular Remodeling(Acute myocardial infarction, basic(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
• PE-096 Persistent elevation in troponin T during convalescence is associated with anemia and inflammatory response in patients with decompensated heart failure(Heart failure, clinical(07)(M),Poster Session(English),The 72nd Annual Scientific Meeting of th
• OE-212 Short-term Experience of Immunoadsorption Therapy for Refractory Heart Failure Due to Dilated Cardiomyopathy(Heart failure, clinical(03)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-107 High velocity peak of ventricular septum during isovolumic contraction period in patients with non-ischemic cardiomyopathy predicts the response to CRT(Echo/Doppler(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanes
• PE-358 The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-905 Remodeling of Cardiac Energy Metabolism under Oxidative Stress to Enhance Regeneration and de novo Synthesis of Glutathione(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
• Cardiac Cell Therapy and Arrhythmias(Mechanisms and Future Challenge)
• OE-235 Transplantation of Artificial Epiardiac Accessory Pathway on Rats with Complete Atrio-Ventricular Block, in Vivo(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
• Transplanted Bone Marrow Stem Cells Move to the Infarcted Myocardium and Regenerate the Heart
• Adult rat cardiomyocytes can divide after myocardial infarction
• 2 Heart Failure Causes Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via Gp130-mediated Cytokines(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-235 Heart Failure Causes Cholinergic Differentiation of Cardiac Sympathetic Nerves Through Paracrine Secreted Factors(Autonomic nervous system(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-172 AAV-PGIS Gene Transfer Improves Hypoxia-induced Pulmonary Hypertension in Mice(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-017 Characterization of the Rejuvenation of Cardiac Sympathetic Nerves in Cardiac Hypertrophy(Autonomic nervous system(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-226 Nerve Growth Factor is Critical for Cardiac Sensory Nerve Development(Autonomic nervous system-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-225 Nerve Growth Factor Rescues Cardiac Sensory Innervation and Silent Myocardial Ischemia in Diabetic Hearts(Autonomic nervous system-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-O95 Cardiac Hypertrophy induces Sympathetic Hyperinnervation concomitant with the Elevation of Endothelin-1 and Nerve Growth Factor(Autonomic nervous system-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-734 Cardiac Sympathetic Nerve Density is Regulated by the Local Endothelin-1-nerve growth Factor Pathway in Adult rat(Cardiac hypertrophy, basic/clinical-4 (M) PJ125,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
• OE-240 A Novel BTB/POZ Protein, RhoBTBS, Negatively Regulates Angiotensin II-induced Cardiac Hypertrophy(Cardiac hypertrophy, basic/clinical-1 (M) OE41,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
• Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca^ channels in the heart
• Marked Improvement with Sildenafil in a Patient with Primary Pulmonary Hypertension Unresponsive to Epoprostenol
• Anisotropic conduction properties: Assessment by high-resolution optical mapping in canine atria
• Induction of ST-Segment Elevation by Regional Myocardial Strech in Normal Canine Hearts in Vivo
• MYOCARDIAL ISCHEMIA IN HEMORRHAGIC SHOCK
• Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
• Stretch-Activated Ion Channel Blocker Gadolinium Attenuates Ischemic ST-Segment Elevation in Canine Myocardium
• Nonischemic ST-Segment Elevation Induced by Negative Inotropic Agents
• -P029- Nonischemic ST segment elevation in duced by negative inotropic agents and myocardial ischemia;Role of regional myocardial contraction on ECG ST segment elevation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0872- Stretch activated channel blocker Gadolinium attenuates ST segment elevation during transmural myocardial ischemia in canine hearts in vivo(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0899-ELECTROPHYSIOLOGICAL SIGNIFICANCE OF DELAYED EPICARDIAL ACTIVATION AS A SUBSTRATE OF LATE POTENTIAL ON THE SIGNAL AVERAGED ELECTROCARDIOGRAM : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Oral Verapamil Attenuates the Progression of Pacing-Induced Electrical and Mechanical Remodeling of the Atrium
• PE-011 The maintenance of intracellular Ca2+ overload in the auto-immunized hypertrophied cardiomyopathy rabbit model(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
• Effect of Chronic Autoimmunity against the Second Extracellular Loop of Beta1-Adrenergic Receptors to Inward Currents in Ventricular Myocytes
• Reversal of Atrial Electrical Remodeling by a Dual L-and T-Type Ca Channel Blocker in Dogs
• Chronic Autoimmunity against Second Extracellular Loop of β1-Adrenergic Receptors Induces Early after Depolarization and Decreases in K-Channel Density in Rabbit
• A T-Type Ca Channel Blocker Efonidipine Prevents Tachycardia-Induced Atrial Remodeling in Dogs
• Where are the potentials recorded in the coronary sinus originated from?
• Analysis of Clockwise and Counterclockwise Reentry around Crista Terminalis in Canine Right Atria by High-resolution Optical Mapping
• Can verapamil prevent pacing-induced electrical and mechanical remodeling of the atrium?
• OJ-486 Granulocyte-Macrophage Colony-Stimulating Factor Inducer Adversely Affects Post-Infarction Left Ventricular Remodeling through Inappropriate Collagen Synthesis and Impaired Infarct Healing(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral P
• Aging Adversely Affects Post-Infarct Inflammatory Response and Left Ventricular Remodeling
• Effect of granulocyte-macrophage colony stimulating factor on left ventricular remodeling after acute myocardial infarction
• Association between peripheral monocytosis and plasma brain natriuretic peptide elevation after reperfused first anterior myocardial infarction
• Significance of neutrophilia and serum C-reactive protein elevation in reperfusion injury after anterior myocardial infarction
• Different effects of carvedilol and metoprolol on the left ventricular remodeling after reperf used anterior myocardial infarction
• Randomized Trial of Phosphodiesterase Inhibitors Versus Catecholamines in Patients With Acutely Decompensated Heart Failure
• 0299 The clinical significance of apical wall motion for the development of mitral regurgitation in acute inferior myocardial infarction
• PJ-222 Evidence that Advanced Parkinson's Disease reveals Complete Cardiac Sympathetic Denervation leading to Cardiovascular Collapse(Autonomic nervous system-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Gene-Modified Cell Transplantation Therapy Expressing hHGF and TK Produces Arteriolar Level Angiogenesis in Murine Hind Limb Ischemia
• Endothelin-1 Disruption Decreases Cardiac Sympathetic Innervation by Downregulation of Nerve Growth Factor
• Angiogenic gene cell therapy using hepatocyte growth factor improves ischemic limb
• Molecular characterization of endothelin-1-specific augmentation of nerve growth factor gene expression in cardiomyocytes
• Comparison between Sirolimus-Eluting Stents Implantation and Directional Coronary Atherectomy for Patients with Ostial Lesions (Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 12 (IHD), The 69th Annual Scientific Meeting of the Japanese C
• Stenting After Directional Coronary Atherectomy Compared With Directional Coronary Atherectomy Alone and Stenting Alone : A Serial Intravascular Ultrasound Study
• PE-081 Hyperthermia following Reperfused Acute Myocardial Infarction is Associated with Early Left Ventricular Remodeling(Acute Myocardial Infarction, Clinical (Pathophysiology) 4 (IHD) : PE14)(Poster Session (English))
• Prognostic Significance of Increased Serum Oxidized LDL after Reperfused Acute Myocardial Infarction
• Serum C-Reactive Protein as a Predictor of Mitral Regurgitation and Left Ventricular Remodeling after First Q-Wave Anterior Acute Myocardial Infarction
• Association between Relative Overactivation of Inflammatory Response and Pump Failure after Reperfused First Q-Wave Acute Myocardial Infarction
• Serum C-reactive protein elevation as a predictor of mural thrombus formation after first anterior myocardial infarction
• Significance of inflammatory response in left ventricular wall thinning and remodeling after acute myocardial infarction
• The percutaneous coronary intervention progresses the stenosis of proximal site to the target lesion
• Comparison of the Effects of Carvedilol and Metoprolol on Exercise Ventilatory Efficiency in Patients With Congestive Heart Failure
• PE-592 Periostin is a Potent Anglogenic Factor and Involved in Degeneration of the Cardiac Valves(Valvular heart disease/Pericarditis/Cardiac tumor(02)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Differential response between cardiomyocytes and cardiac fibroblasts in reactive oxygen spiecies (ROS)-mediated signal transduction pathways by endothelin-1
• Bone marrow-derived regenerated cardiomyocytes (CMG cells) express functional adrenergic and muscarinic receptors
• Leukemia Inhibitory factor activates cardiac L-type Ca^ ERK1/2 is a putative α 1 subunits kinase
• 2 Regulation of Sarcoplasmic Reticulum Ca2+ Leak by Small G-protein Rad in the Heart(Subcellular Remodeling in the Failing Heart,Symposium 10 (SY-10) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-083 Dominant Negative Suppression of Rad Prolongs QT Interval and Causes Ventricular Arrhythmias in Mice(Arrhythmia, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-033 Rad GTPase Negatively Regulates Native L-type Calcium Channel via the Direct Interaction with Calcium Channel β-subunits in Cardiomyocytes(Arrhythmia, basic-2 (A) OJ6,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of th

もっと見る 閉じる

スポンサーリンク