The mode of action of indomethacin, aspirin and melatonin on the blockage of the first ovulation in immature rat pretreated with PMSG.
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概要
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The purpose of this paper was to evaluate the anti-ovulatory effects of indomethacin, aspirin and melatonin by examining the LH sensitive 13, 14-dihydroprostaglandin F<SUB>2α</SUB> forming capacity in rat ovary. When ovulation was blocked by aspirin or melatonin, the forming capacity was strongly suppressed, and these effects were reversed by hCG injection. However, the ovulation blockage by indomethacin did not accompany the inhibition of the forming capacity. These results show that aspirin and melatonin block the ovulation via the hypothalamuspituitary level, and indomethacin acts directly on the ovary.
- 公益社団法人 日本薬理学会の論文
著者
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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KOGO Hiroshi
Department of Pharmacology, Tokyo College of Pharmacy
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TAMURA Kazuhiro
Department of Pharmacology, Tokyo College of Pharmacy
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- The mode of action of indomethacin, aspirin and melatonin on the blockage of the first ovulation in immature rat pretreated with PMSG.
- The possible role of the pituitary gland and uterine tissue in the production system of 13,14-dihydroprostaglandin F2.ALPHA. in rat ovary.