Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta
スポンサーリンク
概要
- 論文の詳細を見る
The influence of the phytoestrogen, isoflavones, on vasodilating responses of the thoracic aorta precontracted with norepinephrine, together with the stimulatory effect on uterine weight (uterotrophic effect), was investigated in ovariectomized rats. In comparison with intact rats, acetylcholine (ACh)-induced vasodilation showed a tendency to be decreased by ovariectomy. On the other hand, isoprenaline (ISO)-induced vasodilation was significantly increased by ovariectomy. Estrogen replacement (17β-estradiol dipropionate, 300 μg/kg per week, for 1 month) completely restored the impaired ACh- and ISO-induced vasodilation caused by ovariectomy. Dietary isoflavone aglycones (containing 52% genistein, 42% daidzein and 6% glycitein) of 157 mg/kg per day (not 67 mg/kg per day) for 1 month, in addition to the effects of estrogen replacement, completely restored the impaired vasodilation caused by ovariectomy. However, the uterotrophic effect of dietary isoflavones of 157 mg/kg per day was incomplete as compared with that by estrogen replacement. These results indicate that phytoestrogen, isoflavones, certainly possess estrogenic actions on the vasodilating responses caused by ACh and ISO, as well as a weaker uterotrophic effect.
- 社団法人 日本薬理学会の論文
- 2001-09-01
著者
-
Yamaguchi Kiyoshi
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
-
Honda H
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
-
Honda Hideo
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
-
Honda Hideo
Department Of Ophthalmology Nagoya City University Medical School
-
KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
-
Kogo H
Department Of Pharmacology Tokyo College Of Pharmacy
-
Kogo Hiroshi
東京薬科大学 内分泌分子薬理学
-
Kogo Hiroshi
Department Of Electrical Engineering Chiba University
-
Kogo H
Deparfment Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
-
Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
-
Yamaguchi Kiyoshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
-
Yamaguchi Kiyoshi
Department Of Geriatric Medicine Graduate School Of Medicine University Of Tokyo
-
Tohei Atsushi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
-
WAKISAKA Chiaki
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
-
Honda Hideo
東京薬科大学 薬理
-
Yamaguchi Kiyoshi
Department Of Electronic Engineering Osaka Institute Of Technology
-
Wakisaka Chiaki
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
関連論文
- PE-498 Augmented Cholesterol Absorption in Patients Treated with Strong Statins(PE084,Lipid Disorders 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- Temporal Expression of Type I Interferon Receptor in the Peri-Implantation Ovine Extra-Embryonic Membranes : Demonstration that Human IFNα Can Bind to This Receptor
- Estimation of the Surface Magnetic Structure of Materials by Scanning Electron Microscopy
- EFFECT OF PREGNANT MARE SERUM GONADOTROPIN AND ESTRADIOL ON THE FORMATION OF 13,14-DIHYDROPROSTAGLANDIN F_ IN RAT OVARY
- Sequestration of Cross-linked Membrane Molecules to Caveolae in Two Different Pathways
- Caveolae: from a morphological point of view
- Molecular Mechanism for the Expression of Caveolin-1 Isoforms : Relevance to the Formation of Caveolar Invagination
- Direct Ovarian Effects of a GnRH Agonist in Hypophysectomized Immature Rats : Inhibition of Theca-Interstitial Luteinizing Hormone Receptor mRNA Expression and Induction of Interstitial Cell Differentiation(Reproductive Biology)
- MUTUALLY EXCLUSIVE EXPRESSION OF CAVEOLIN-1 ISOFORMS IN THE DIFFERENT CELL TYPES OF THE MOUSE LUNG(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- A-16 Caveolin-1 and Structure of Caveolae
- Caveolae and Endoplasmic Reticulum : Immunofluorescence Microscopy and Time-Lapse Analysis
- Acousto-Optic Bragg Diffraction by Deep Bulk Acoustic Waves for Use in Optic Spectrum Analyser : Photoacoustic Spectroscopy
- Propagation Characteristics of SAW on a ZnO/SiO_2/high-velocity-substrate Structure : SAW and Communication Devices
- Effect of Surface Electrical Boundary Condition on Temperature Stability of SAW Devices : SAW and Communication Devices
- Accuracy of Gates RF Pulse Measurement : Acoustical Measurements and Instrumentation
- High-Frequency Operation for Resin-Coated BAW Beam Devices : SAW and Communication Devices
- Automated Acousto-Optic Measurement System of Bluk Acoustic Waves Launched from an IDT : Acoustical Measurements and Instrumentation
- Role of BK Channels in Testosterone-Induced Relaxation of the Aorta in Spontaneously Hypertensive Rats(Pharmacology)
- Dexamethasone or Triamcinolone Increases Follicular Development in Immature Female Rats
- Evaluation of low back pain using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for lumbar spinal disease in a multicenter study : differences in scores based on age, sex, and type of disease
- Prostaglandin F_ -Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents
- EFFECT OF 13, 14-DIHYDROPROSTAGLANDIN F2α ON STEROID BIOSYNTHESIS IN RAT OVARY
- EFFECT OF GONADOTROPIN AND ESTROGEN ON CHANGES IN LEVELS OF PROSTAGLANDIN IN RAT OVARY
- Short Term Hypercholesterolemia Alters N^G-Nitro-L-arginine-and Indomethacin-Resistant Endothelium-Dependent Relaxation by Acetylcholine in Rabbit Renal Artery
- SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
- Effect of Etidronate on Aortic Calcification and Bone Metabolism in Calcitoriol-Treated Rats With Subtotal Nephrectomy
- Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta
- 17β-Estradiol Alters Isoproterenol-Induced Relaxation in Rat Aortic Rings
- ROLE OF PHOSPHOLIPID IN THE EFFECT OF ESTRADIOL ON SUGAR TRANSPORT IN RAT UTERUS
- EFFECT OF METHYLXANTHINES ON URINARY PROSTAGLANDIN E EXCRETION IN RATS
- EFFECT OF THEOPHYLLINE ON THE RELEASE AND CONTENTS OF PROSTAGLANDINS E AND F IN RAT
- EFFECT OF INTRA-UTERINE ADMINISTRATION OF INDOMETHACIN ON OVARIAN STEROIDS
- EFFECT OF OXYTOCIN AND ESTROGEN ON PROSTACYCLIN RELEASE FROM ISOLATED UTERUS IN OVARIECTOMIZED RATS
- EFFECT OF PHOSPHOLIPASE A, C, AND D ON SUGAR AND AMINO ACID TRANSPORT IN RAT UTERUS
- Cross-Reactive Mechanism for the False Elevation of Free Triiodothyronine in the Patients Treated with Diclofenac
- Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment
- Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment
- THE ROLE OF UTERINE TISSUE IN CHANGES OF PROSTAGLANDIN CONTENT IN THE RAT OVARY
- Vitality Index as a useful tool to assess elderly with dementia
- ANTHROPOLOGICAL OBSERVATIONS ON PROTRUSION OF THE EYEBALLS IN THE LIVING JAPANESE BODY
- Effect of Thyroid Hormone on CYP19 Expression in Ovarian Granulosa Cells From Gonadotropin-Treated Immature Rats
- Involvement of Stathmin in Proliferation and Differentiation of Immortalized Human Endometrial Stromal Cells
- The Expression of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells
- Analysis of the Image Formation Mechanism on High Energy Scanning Electron Microscopy
- Influence of OSW-1 [3β, 16β, 17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a Steroidal Saponin, on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta
- GONADOTROPIN-RELEASING HORMONE RECEPTOR mRNA EXPRESSION IN THE OVARIES OF NEONATAL AND ADULT RATS
- EFFECT OF VASOPRESSIN ON RAT URINARY PROSTAGLANDIN EXCRETION
- ANALYSIS OF KOHLRAUSCH'S BEND
- A METHOD FOR CHECKING OF TONOMETERS
- Plasma sex hormone levels and mortality in disabled older men and women
- Significance of Phospholipid in Estrogen Action on Rat Uterus
- Acetylcholine-Induced Relaxation of Rat Aorta Is Greatest during Estrus in the Sexual Cycle
- A Comparison of the Effects of Estradiol and 2- and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats.
- Inhibitory effect of acemetacin, a prodrug of indomethacin, on prostaglandin E2 release from inflamed synovial tissue.
- Effects of Antiestrogens on Ovarian Aldo-Keto Reductase in Relation to Ovulation in Rats.
- Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands
- Agonistic-Antagonistic Actions of Clomiphene Citrate on PGF2.ALPHA. Fluctuations in Ovariectomized Rat Uterus.
- RELATION BETWEEN THE TENSION AND THE RADIUS OF THE CORNEA
- The mode of action of indomethacin, aspirin and melatonin on the blockage of the first ovulation in immature rat pretreated with PMSG.
- The possible role of the pituitary gland and uterine tissue in the production system of 13,14-dihydroprostaglandin F2.ALPHA. in rat ovary.