Expression and Potential Role of GATA Factors in Trophoblast Development

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概要

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• Despite exhaustive studies, molecular mechanisms governing blastocyst formation, implantation to the uterine endometrium and placentation have not been definitively characterized. GATA family proteins are a group of zinc finger transcription factors, for which gene ablations eventually result in embryonic death later in pregnancy. These findings suggested that GATA factors are not essential for early embryonic development. However, recent studies from our laboratory and others have revealed that GATA proteins are involved in the regulation of key genes expressed by the trophectoderm that underpin the transition from the morula to trophoblast, and trophectoderm maintenance. Consequently, it is important to consider the current understanding how GATA factors govern early trophectoderm development.

• 日本繁殖生物学会の論文

著者

• Imakawa Kazuhiko

  Laboratory Of Animal Breeding And Reproduction Department Of Veterinary Medical Sciences Graduate Sc

• Sakurai Toshihiro

  Laboratory Of Animal Breeding And Reproduction Veterinary Medical Sciences Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• GODKIN James

  Department of Animal Science, University of Tennessee

• BAI Hanako

  Research Fellow of the Japan Society for the Promotion of Science (JSPS Research Fellow)

• GODKIN James

  Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA

• SAKURAI Toshihiro

  Laboratory of Animal Breeding, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo 113-8657, Japan

• IMAKAWA Kazuhiko

  Laboratory of Animal Breeding, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo 113-8657, Japan

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• 反芻動物の着床期胚・栄養膜細胞における転写因子GATA6の発現と機能
• Expression and Potential Role of GATA Factors in Trophoblast Development
• Expression and Potential Role of GATA Factors in Trophoblast Development
• Expression of Endometrial Immune-related Genes Possibly Functioning During Early Pregnancy in the Mare

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