Effects of Glucose-Induced Insulin Secretion on Ventricular Repolarization in Patients With Congenital Long QT Syndrome
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概要
- 論文の詳細を見る
To assess the role of insulin in ventricular repolarization in patients with congenital long QT syndrome(LQTS), an oral glucose tolerance(OGT)test was performed in 11 patients with LQTS and in 11 control cases without QT prolongation. Plasma glucose, potassium level and the immunoreactive insulin concentration(IRI)were measured, and the QT interval and T wave morphology on 12-lead ECG were analyzed during fasting and after glucose load. The LQTS group had a higher incidence of changes in T wave morphology, such as biphasic, bifid or notched T wave, after glucose load than the control group(11 of 11 patients[100%]vs 0 of 11[0%]; p<0.0001). The T wave changes returned to baseline at 180min after glucose load in 7 patients. The maximal QT interval and QT dispersion increased significantly and returned to baseline level in response to IRI after glucose load in LQTS, whereas the QT interval was unaffected in the control group. After glucose load, ventricular arrhythmias and T wave alternans were observed in 3 and 1 patients with LQTS, respectively, but none in the control group. The findings suggest that glucose-induced insulin secretion plays a role in inducing abnormalities and inhomogeneity of ventricular repolarization in patients with LQTS.
- 社団法人日本循環器学会の論文
- 2001-12-20
著者
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NISHIZAKI Mitsuhiro
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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YAMAWAKE Noriyoshi
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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ASHIKAGA Takashi
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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FUJII Hiroyuki
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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SAKURADA Harumizu
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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HIRAOKA Masayasu
Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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Sumitomo Naokata
Department of Pediatrics, Nihon University School of Medicine
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Sumitomo Naokata
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Sakurada Harumizu
Department Of Cardiology Metropolitan Hiroo Hospital
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Sumitomo Naokata
Nihon University School Of Medicine Department Of Pediatrics
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Fujii Hiroyuki
Department Of Cardiology Yokohama-minami Kyosai Hospital
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Sumitomo Naokata
Department Of Pediatrics Nihon University School Of Medicine
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Arita Masataka
Departments of Cardiology, Yokohama Minami Kyosai Hospital
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Hiraoka Masayasu
Department Of Cardilvascular Disease Medical Research Institute Tokyo Medical And Dental University
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Yamawake Noriyoshi
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Arita Masataka
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Nishizaki Mitsuhiro
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Ashikaga Takashi
Department Of Cardiology Wakayama Medical University
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Ashikaga Takashi
Cardiovascular Center Yokosuka Kyosai Hospital
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SUMITOMO Naokata
Department of Pediateics and Child Health, Nihon University School of Medicine
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