Low Risk for Arrhythmic Events in Asymptomatic Patients With Drug-Induced Type 1 ECG : Do Patients With Drug-Induced Brugada Type ECG Have Poor Prognosis? (Con)
スポンサーリンク
概要
- 論文の詳細を見る
The type 1 ST-segment elevation is diagnostic for Brugada syndrome (BS) and its presence may sometimes be associated with a high risk of arrhythmic events. The type 1 ECG is also known to be unmasked by administration of sodium-channel blockers in equivocal or suspected cases of BS, and the drug-challenge test is frequently used in the diagnostic approach. In large cohort studies the spontaneous appearance of the type 1 ECG with symptoms of aborted sudden death or unexplained syncope are indicative of a poor prognosis for patients with BS compared with not having clinical symptoms. Therefore, the spontaneous type 1 ECG appears to represent an important predictive sign for cardiac events. It is unknown, however, whether or not the drug-induced type 1 ECG is as useful as the spontaneous type 1 for predicting cardiac events in asymptomatic subjects showing non-type 1 ECG. Review of the literature for large cohort studies indicates that there is a low incidence of arrhythmic events in asymptomatic patients with either the spontaneous or drug-induced type 1 ECG compared with symptomatic subjects, and the drug-induced type1 ECG in asymptomatic patients does not add to an increase in arrhythmic risk. Therefore, drug testing to unmask the type 1 ECG in asymptomatic patients with a non-type 1 BS ECG does not have an additional value for risk stratification of cardiac events, although it might be useful in symptomatic patients showing only the non-type 1 ECG. (Circ J 2010; 74: 2464-2473)
- 2010-10-25
著者
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NISHIZAKI Mitsuhiro
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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YAMAWAKE Noriyoshi
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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SAKURADA Harumizu
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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HIRAOKA Masayasu
Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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Sakurada Harumizu
Department Of Cardiology Tokyo Metropolitan Hiroo Hospital
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Hiraoka M
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Hiraoka Masayasu
Tokyo Medical and Dental Uni.
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Sakurada Harumizu
Department Of Cardiology Metropolitan Hiroo Hospital
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Hiraoka Masayasu
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Hiraoka Masayasu
Depertment Of Cardiovascular Disease Medical Research Institute Tokyo Medical And Dental University
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Sakurada Harumizu
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Matsuda Hisao
Kawasaki Municipal Tama Hospital Cardiovascular Division
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Hiraoka Masayasu
Tokyo Medical And Dental University
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Hiraoka Masayasu
Department Of Cardiovascular Disease Medical Research Institute Tokyo Medical And Dental University
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Hiraoka Masayasu
Kawasaki Municipal Tama Hospital Cardiovascular Division
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Ueda Tatsumoto
Department Of Cardiology Tokyo Metropolitan Hiroo Hospital
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Nishizaki Mitsuhiro
Department Of Cardiology Yokohama-minami Kyosai Hospital
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Yamawake Noriyoshi
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Nishizaki Mitsuhiro
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Hiraoka Masayasu
Department Of Cardiovascular Diseases Division Of Medical Science Medical Research Institute Tokyo M
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Matsuda Hisao
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Hiraoka Masayasu
Department Of Cardiovascular Internal Medicine St. Marianna University School Of Medicine Hospital
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