A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
Intravenous administration of 5-FU 15 mg/kg significantly lowered the blood pressure 17 hours after, while ftorafur 20 mg/kg did not alter the pressure. Ftorafur 60 mg/kg significantly lowered the pressure 17 hours after the drug administration. In a large number of rabbits treated with 5-FU 15 mg/kg or ftorafur 60 mg/kg, the ventricular fibrillation spontaneously produced within 17 hours after the treatment. Adrenaline 5-50 μg/kg was injected into an ear vein in a stepwise manner, to assess whether or not the drug would induce a ventricular fibrillation. Pretreatment with 5-FU 15 mg/kg <SUB>"</SUB>sensitized" the ventricle to adrenaline-induced ventricular fibrillation, while ftorafur 20 and 60 mg/kg did not. The time required to produce ventricular fibrillation after a large dose (200 μg/kg) of ouabain was significantly shorter in 5-FU 15 mg/kg and ftorafur 60 mg/kg treated (17 hours before) groups than in the control group, while in the ftorafur 20 mg/kg treated group, the time was much the same as seen in the control group. These findings indicate that the cardiotoxicity of ftorafur in rabbits may be weaker than that of 5-FU.
- 社団法人 日本薬理学会の論文
著者
-
Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
-
NAKANISHI Hironori
Department of Pharmacology, Fukushima Medical College
-
Nakanishi Hironori
Department Of Pharmacology Fukushima Medical College
-
SUZUKI Takehiko
Department of Industrial Chemistry, Faculty of Technology, Tokyo Metropolitan University
-
Suzuki Takehiko
Department Of Geography Tokyo Metropolitan University
-
Suzuki Takehiko
Department of Chemistry, Nagoya University
関連論文
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Inhibitory Effect of Ethanol Extract of Piper longum L. on Rabbit Platelet Aggregation through Antagonizing Thromboxane A_2 Receptor(Pharmacology)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- The Uterus Sustains Stable Biological Clock during Pregnancy
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- THROMBOXANE A_2 RECEPTORS IN RABBIT CULTURED ASTROCYTES
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells