Inhibitory Effects of Dehydrocorydaline Isolated from Corydalis Tuber against Type I-IV Allergic Models
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概要
- 論文の詳細を見る
An alkaloidal component, dehydrocorydaline (DHC) isolated from Corydalis Tuber (tuber of Corydalis turtschaninovii forma yanhusuo), has been screened for ctivity against types I-IV allergic reactions. In a type I allergic models, DHC at a dose of 0.5 mmol/kg, p.o. inhibited 48h homologous passive cutaneous anaphylaxis (PCA) in rats, which is related to IgE. DHC also exhibited an inhibitory effect on antigen-induced histamine release from peritoneal mast cells. In a type II allergic model, DHC did not inhibit reversed cutaneous anaphylaxis (RCA) in rats. In a type III allergic model, DHC showed weak inhibition on direct passive arthus reaction (DPAR) in rats. Furthermore, in a type IV allergic model, DHC had inhibitory effects on the induction phase and effector phase in picryl chloride-induced contact dermatitis (PC-CD). These results indicated that DHC not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to DHC.
- 社団法人日本薬学会の論文
- 1997-04-15
著者
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角谷 真
京都薬科大学
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Kubo Michinori
近畿大学 薬学部
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KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
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TOKUOKA Kiyoshi
Faculty of Pharmaceutical Sciences, Kinki University
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WU Jianxin
Faculty of Pharmaceutical Sciences, Kinki University
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SHIOMOTO Hidemi
Faculty of Pharmaceutical Sciences, Kinki University
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Wu Jianxin
Faculty Of Pharmaceutical Sciences Kinki University
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Tokuoka K
Faculty Of Pharmaceutical Sciences Kinki University
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Tokuoka Kiyoshi
近畿大学 薬
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Tokuoka Kiyoshi
Faculty Of Pharmaceutical Sciences Kinki University
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Shiomoto H
Faculty Of Pharmaceutical Sciences Kinki University
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Shiomoto Hidemi
静岡県立大学 食品栄養科
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Shiomoto Hidemi
Pharmacological Evaluation Laboratory Self Medication Laboratories Taisho Pharmaceutical Co. Ltd.
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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