Effect of Dietary Amino Acids on Behavior and Serum Levels of Amino Acids in Stress Loaded Rats.
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概要
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Interrelationships between behavior and concentrations of serum amino acids in stressed rats with immobilization and water immersion were investigated. Rats were subjected to 7h of immobilization with water-immersion stress (IWS) in each sequential day, and serum amino acids were then determined. On the first day, serum taurine, threonine, valine, leucine, isoleucine, phenylalanine, lysine, and histidine (increased-type of amino acids) were significantly increased, but alanine (decreased-type) was significantly de-creased. On days 3 and 7, the increase was retained, except for threonine, histidine, and ly-sine. Spontaneous activities (locomotion, rearing behavior, hole-poking) under loading water-immersion stress were significantly decreased, but a supplementation of branchedchain amino acids (BCAA) led to recovery. We suggest that pretreatment with some kind of increased type of amino acid, such as BCAA, might effectively prevent decline in spontaneous activities evoked by water-immersion stress.
著者
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Shiomoto Hidemi
Pharmacological Evaluation Laboratory Self Medication Laboratories Taisho Pharmaceutical Co. Ltd.
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Yokogoshi Hidehiko
Laboratories Of Nutritional Biochemistry School Of Food And Nutritional Sciences The University Of S
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Osada Kazumi
Pharmacological Evaluation Laboratory Self Medication Laboratories Taisho Pharmaceutical Co. Ltd.
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Kitajima Hideaki
Laboratory Of Mineral Nutrition Division Of Human Nutrition Incorporated Administrative Agency Of He
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YOKOGOSHI Hidehiko
Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences. University of Shizuoka
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SHIOMOTO Hidemi
Pharmacological Evaluation Laboratory, Self Medication Laboratories, Taisho Pharmaceutical Co., Ltd.
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