Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats
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概要
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The present study was designed to gain insight into the effects of s-limonene on the brain after 1-wk administration. For this purpose, neurotransmitters such as dopamine (DA), serotonin (5-HT), γ-aminobutyric acid (GABA), glutamic acid (Glu) and some of their metabolites (DOPAC and 5-HIAA) were determined by HPLC-ECD and amino acid analyzer after 1-wk administration of s-limonene of different concentrations (0, 5, 25, 50 mg/kg). Significant changes, such as GABA, 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT, were confirmed. At the same time, basal hypothalamic-pituitary-adrenal (HPA) activity after 1-wk administration of s-limonene was evaluated by corticosterone. Considering the increment of GABA and the changes of other neurotransmitters, anti-stress effects after 1-wk administration were observed. The experimental results showed that s-limonene could inhibit HPA activity under physical stress and this anti-stress effect of s-limonene may act through the GABAA receptor.
- 2009-08-01
著者
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ZHOU Wenjun
Laboratory of Nutritional Biochemistry, Global COE Program in the 21st Century, Graduate School of N
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YOSHIOKA Miyuki
Laboratory of Nutritional Biochemistry, Global COE Program in the 21st Century, Graduate School of N
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YOKOGOSHI Hidehiko
Laboratory of Nutritional Biochemistry, Global COE Program in the 21st Century, Graduate School of N
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Yokogoshi Hidehiko
Laboratory Of Nutritional Biochemistry School Of Food And Nutritional Sciences Coe Program In The 21
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Yokogoshi Hidehiko
Laboratories Of Nutritional Biochemistry School Of Food And Nutritional Sciences The University Of S
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Yokogoshi Hidehiko
Laboratory Of Nutritional Biochemistry School Of Food And Nutritional Sciences University Of Shizuok
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Yokogoshi Hidehiko
Laboratory Of Nutritional Biochemistry Global Coe Program In The 21st Century Graduate School Of Nut
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Zhou Wenjun
Laboratory Of Nutritional Biochemistry Global Coe Program In The 21st Century Graduate School Of Nut
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Yoshioka Miyuki
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Yokogoshi Hidehiko
Lab. Of Nutritional Biochemistry Univ. Of Shizuoka
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