Effect of Different Dietary Protein Composition on Skeletal Muscle Atrophy by Suspension Hypokinesia/Hypodynamia in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Under microgravity conditions similar to those in space, it is known that various nutritional and physiological changes in the body are induced. Especially in the aspect of nutrition, muscle atrophy is a characteristic phenomenon accompanying weightlessness. This study was conducted to investigate the ameliorated effect of muscle atrophy caused by suspension hypokinesia by using the soy protein isolate (SPI) as the protein source in comparison with casein. Male Wistar strain rats (8 wk old) were divided into two groups, each suspended with a suspension harness, and fed on a 20% SPI diet or a 20% casein diet for 10d. The body weights of the suspended rats fed casein or SPI decreased similarly. The weight of the gastrocnemius and soleus muscle were decreased by suspension hypokinesia; however, the degree of the decrease of the muscle weights, especially soleus muscles, of rats fed the SPI diet was smaller than that of rats fed the casein diet. Serum Nτ-methylhistidine concentration was significantly lower in rats fed the SPI diet than in rats fed the casein diet. Similarly, the activities of muscle protein-degrading enzymes such as calpain and proteasome were significantly lower in rats fed the SPI diet than in rats fed the casein diet. Cathepsin B+L activities were not affected by the SPI or the casein diet. Therefore it is suggested that SPI caused a reduction of the proteolysis of myofibrillar protein in skeletal muscles through a reduction of calpain and proteasome activities, in consequence to ameliorate the muscle atrophy.
- 財団法人 学会誌刊行センターの論文
- 2002-04-01
著者
-
Yokogoshi Hidehiko
Laboratories Of Nutritional Biochemistry School Of Food And Nutritional Sciences The University Of S
-
Tada Osamu
Laboratory Of Nutritional Biochemistry Graduate School Of Nutritional And Environmental Sciences The
-
Yokogoshi Hidehiko
Laboratory Of Nutritional Biochemistry Graduate School Of Nutritional And Environmental Sciences The
関連論文
- Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats
- Dietary γ-Aminobutyric Acid Affects the Brain Protein Synthesis Rate in Ovariectomized Female Rats
- Effects of Quantity and Quality of Dietary Protein on the Brain Polysome Profile in Aged Rats(Food & Nutrition Science)
- Co-Administration of Proline and Inorganic Iron Enhance the Improvement of Behavioral and Hematological Function of Iron-Deficient Anemic Rats
- Effect of Dietary Amino Acids on Behavior and Serum Levels of Amino Acids in Stress Loaded Rats
- EFFECTS OF DOPAMINERGIC AGENTS ON IMPULSIVITY AND INTRACEREBRAL MONOAMINES IN THE DOMESTIC CHICK(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Dose-dependent Changes in Brain 5-Hydroxyindoles Caused by Caffeine in Rats
- Effect of Quality and Quantity of Dietary Protein on 4E-BP1 and S6K1 Phosphorylation of Brains in Aged Rats
- Effects of Suspension Hypokinesia/Hypodynamia on Morphometric Measurements of Rat Muscle Fibers(Food & Nutrition)
- Changes in N-Acetylglutamate Are Involved in Regulating Urea Synthesis in Rats Given a Low Gluten Diet Supplemented with L-Lysine, L-Methinone and L-Threonine