Anti-Inflammatory Activities of Dehydrocorydaline Isolated from Corydalis Tuber

概要

論文の詳細を見る
The inhibitory effects of dehydrocorydaline (DHC), a major component from Corydalis Tuber (tuber of Corydalis turtschaninovii forma yanhusuo, Papaveraceae), on acute inflammatory models were investigated. Oral administration of DHC at 0.125 mmol/kg inhibited the increases in the acetic acid-induced vascular permeability and the increase in the carrageenin-induced paw edema in mice. It exhibited an inhibitory effect on the edema derived by serotonin or bradykinin but no effect on the edema derived by histamine. It also showed inhibitory effects on the increase of ear edema induced by arachidonic acid (AA) and its metabolites, mixture of prostaglandin E_2 (PGE_2) and leukotriene C_4 (LTC_4). These results suggested that DHC might be considered to be a potent anti-inflammatory component in Corydalis Tuber, although its mechanisms have not yet been fully understood.
日本生薬学会の論文
1997-08-20